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2-氨基-6-氯嘌呤

2-氨基-6-氯嘌呤用途

6-氯鸟嘌呤是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

2-氨基-6-氯嘌呤名称

[ CAS 号 ]:
10310-21-1

[ 中文名 ]:
2-氨基-6-氯嘌呤

[ 英文名 ]:
2-Amino-6-chloropurine

[中文别名 ]:

6-氯鸟嘌呤

[英文别名 ]:

2-Amino-6-Chloro-Purin
2-Amino-6-chloropurine
MFCD00075252
EINECS 233-686-7
6-Chloroguanine
9H-Purin-2-amine, 6-chloro-
6-Chloro-3H-purin-2-amine
2-AMINO-6-CHLORO-PURINE

2-氨基-6-氯嘌呤生物活性

[ 描述 ]:

6-氯鸟嘌呤是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

2-氨基-6-氯嘌呤是合成核苷酸类似物的前体,具有抗爱泼斯坦-巴尔病毒 (EBV)和人类疱疹病毒 6(HHV-6)的抗病毒活性。11.邱,Y.-L.,克塞巴蒂,MB,Ptak,RG等人(Z)-和 (E) -2-((羟甲基)环亚丙基)甲基丹宁和-鸟嘌呤具有广谱抗病毒活性的新型核苷酸类似物 J医学。化学 41(1)10-23(1998)

[参考文献]

[1]. Qiu, Y.-L., Ksebati, MB, Ptak, RG, et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleotide analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1) 10-23 (1998).

2-氨基-6-氯嘌呤物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
315.2ºC at 760mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₅H₄ClN₅

[ 分子量 ]:
169.57

[ 闪点 ]:
144.4ºC

[ 精确质量 ]:
169.015518

[ PSA ]:
80.48000

[ LogP ]:
-0.03

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
1.75E-15mmHg at 25°C

[ 折射率 ]:
1.827

[ 储存条件 ]:
Keep Cold

[ 水溶解性 ]:
1.7 g/L (20 ºC)

2-氨基-6-氯嘌呤MSDS

2-氨基-6-氯嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7502000

CHEMICAL NAME :: Purine, 2-amino-6-chloro-

CAS REGISTRY NUMBER :: 10310-21-1

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H4-Cl-N5

MOLECULAR WEIGHT :: 169.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mg/L/24H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,149,1984

2-氨基-6-氯嘌呤安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi,Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UO7502000

[ 海关编码 ]:
2933990090

2-氨基-6-氯嘌呤合成路线

2-氨基-6-氯嘌呤上下游产品

2-氨基-6-氯嘌呤上游产品

2-氨基-6-氯嘌呤下游产品

2-氨基-6-氯嘌呤制备

可用2,9-二酰基鸟嘌呤或2,4,5-三氨基-6-氯嘧啶制取。

2-氨基-6-氯嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基-6-氯嘌呤文献

The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.

Bioorg. Med. Chem. 15 , 3450-6, (2007)

Xanthine oxidase (XO) is a key enzyme which can catalyze xanthine to uric acid causing hyperuricemia in humans. By using the fractionation technique and inhibitory activity assay, an active compound t...

Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.

Nucleic Acids Res. 43 , 4087-97, (2015)

Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowd...

Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.

J. Org. Chem. 74(6) , 2616-9, (2009)

Upon reacting 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal S-oxide (6) with Ac(2)O/TMSOAc/BF(3) x OEt(2) in CH(2)Cl(2), the additive Pummerer reaction proceeded to furnish the corresponding 1,2...

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