1,4-苯醌二肟

1,4-苯醌二肟用途

【用途一】
用作测定镍的试剂及橡胶硫化剂
【用途二】
用作丁基橡胶、天然橡胶、丁苯橡胶等的硫化剂
【用途三】
用作丁基胶、天然胶、丁苯胶、聚硫“ST”型橡胶的硫化剂，特别适用于丁基胶。氧化剂（如Pb3O4，PbO2）对其有活化作用。在胶料中易分散，硫化快，硫化胶拉伸强度高。临界温度比较低，有焦烧倾向。加入某些防焦剂（如苯酐，防焦剂NA）、秋兰姆、噻唑类、二硫代氰基甲酸盐类促进剂能有效地改善操作安全性。该品有变色及污染剂，只适用于暗色制品。当用促进剂DM作活性剂时，抗焦烧性要比氧化铅好，变色性也减弱，但炭黑胶料例外。当以四氯苯醌为活性剂时，活化作用比氧化铅强得多。该品主要用于制造气囊、水胎、电线电缆的绝缘层、耐热垫圈等。用量1-2份。与氧化铅10-6份或促进剂DM4-2份配合。对苯醌二肟是测定镍的试剂。

1,4-苯醌二肟名称

[ CAS 号 ]:
105-11-3

[ 中文名 ]:
1,4-苯醌二肟

[ 英文名 ]:
p-Benzoquineone dioxime

[中文别名 ]:

对苯醌二肟

[英文别名 ]:

2,5-Cyclohexadiene-1,4-dione, dioxime, (1Z,4Z)-
p-Quinone dioxime (p-Benzoquinone dioxime)
p-Quinone Dioxime
2,5-Cyclohexadiene-1,4-dione, dioxime, (1E,4E)-
1,4-Benzoquinone dioxime
N-(4-nitrosophenyl)hydroxylamine
p-Benzoquineone dioxime
p-Benzoquinonedioxime
EINECS 203-271-5
MFCD00063636

1,4-苯醌二肟物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
303.0±42.0 °C at 760 mmHg

[ 熔点 ]:
243 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₆N₂O₂

[ 分子量 ]:
138.124

[ 闪点 ]:
182.5±17.1 °C

[ 精确质量 ]:
138.042923

[ PSA ]:
65.18000

[ LogP ]:
1.89

[ 外观性状 ]:
淡黄色至棕色晶体或粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.594

[ 储存条件 ]:
-20°C

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ 水溶解性 ]:
<0.01 g/100 mL at 22.5 ºC

1,4-苯醌二肟MSDS

详细MSDS(安全技术说明书)

1,4-苯醌二肟毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK4900000

CHEMICAL NAME :: p-Benzoquinone, dioxime

CAS REGISTRY NUMBER :: 105-11-3

BEILSTEIN REFERENCE NO. :: 2043234

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C6-H6-N2-O2

MOLECULAR WEIGHT :: 138.14

WISWESSER LINE NOTATION :: L6Y DYJ AUNQ DUNQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1456 mg/kg/35W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 25 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,85,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,185,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,185,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81967 No. of Facilities: 45 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 732 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81967 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 1811 (estimated) No. of Female Employees: 17 (estimated)

1,4-苯醌二肟安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R40

[ 安全声明 (欧洲) ]:
S45-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DK4900000

[ 海关编码 ]:
2942000000

1,4-苯醌二肟合成路线

详细合成路线

1,4-苯醌二肟上下游产品

1,4-苯醌二肟上游产品

1,4-苯醌二肟下游产品

1,4-苯醌二肟制备

先将30%的氢氧化钠溶液加入反应釜，在搅拌下缓缓将苯酚加入，使之溶于氢氧化钠溶液。降温至0℃再加入亚硝酸钠和30%的硫酸，使温度保持在7～8℃进行反应，逐渐有亚硝基酚结晶析出。搅拌1h后，静置过滤，结晶经水洗，得亚硝基酚。再经转位，与盐酸羟胺水溶液混合，加热至70℃进行肟化反应。反应完成后，过滤得对苯醌二肟。

1,4-苯醌二肟海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

1,4-苯醌二肟文献

In vivo genotoxicity studies with p-benzoquinone dioxime.

Environ. Mol. Mutagen. 19(1) , 71-6, (1992)

P-Benzoquinone dioxime (BQD) appears to be a sex-specific rat carcinogen inducing tumours of the urinary bladder in female rats. The present paper shows that BQD is a direct-acting mutagen in Salmonel...

para-Benzoquinone dioxime.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 29 , 185-91, (1982)

1,4-Benzoquinone dioxime.

IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1251-4, (1999)

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