丙烯腈_MSDS_用途_密度_丙烯腈CAS号【107-13-1】

【用途一】
用作色谱分析标准物质，也用于橡胶、塑料、有机合成及杀虫剂的制造
【用途二】
用于合成聚丙烯腈、尼龙66、丁腈橡胶、ABS树脂、聚丙烯酰胺、丙烯酸酯类等，也用作谷物烟熏剂
【用途三】
丙烯腈是杀菌剂溴菌腈、霜霉威，杀虫剂毒死蜱和杀虫双、杀螟丹的中间体，还可以制备二氯菊酸甲酯用以生产拟除虫菊酯，也是杀虫剂虫满腈的中间体。
【用途四】
丙烯腈是合成纤维，合成橡胶和合成树脂的重要单体。由丙烯腈制得聚丙烯腈纤维即(腈纶)，其性能极似羊毛,因此也叫(合成羊毛)。丙烯腈与丁二烯共聚可制得丁腈橡胶，具有良好的耐油性，耐寒性，耐磨性，和电绝缘性能，并且在大多数化学溶剂，阳光和热作用下，性能比较稳定。丙烯腈与丁二烯，苯乙烯共聚制得ABS树脂，具有质轻,耐寒,抗冲击性能较好等优点。丙烯腈水解可制得丙烯酰胺和丙烯酸及其酯类。它们是重要的有机化工原料，丙烯腈还可电解加氢偶联制得己二腈，由己二腈加氢又可制得己二胺，己二胺是尼龙66原料。可制造抗水剂和胶粘剂等，也用于其他有机合成和医药工业中，并用作谷类熏蒸剂等。此外，本品也是一种非质子型极性溶剂。

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
77.3±0.0 °C at 760 mmHg

[ 熔点 ]:
-83.5 °C

[ 分子式 ]:
C₃H₃N

[ 分子量 ]:
53.063

[ 闪点 ]:
0.0±0.0 °C

[ 精确质量 ]:
53.026550

[ PSA ]:
23.79000

[ LogP ]:
0.19

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
1.83 (vs air)

[ 蒸汽压 ]:
97.1±0.1 mmHg at 25°C

[ 折射率 ]:
1.385

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、碱类分开存放

[ 水溶解性 ]:
Soluble. 7.45 g/100 mL

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AT5250000

CHEMICAL NAME :: Acrylonitrile

CAS REGISTRY NUMBER :: 107-13-1

BEILSTEIN REFERENCE NO. :: 0605310

LAST UPDATED :: 199806

DATA ITEMS CITED :: 139

MOLECULAR FORMULA :: C3-H3-N

MOLECULAR WEIGHT :: 53.07

WISWESSER LINE NOTATION :: NC1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Non-standard exposure

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 16 ppm/20M

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1 gm/m3/1H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 2015 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 425 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Endocrine - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 110 ppm/4H

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >90 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 600 ppm/4H

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 260 ppm/4H

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 69 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 575 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - cough

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/1Y-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/21D-C

TOXIC EFFECTS :: Endocrine - other changes Nutritional and Gross Metabolic - changes in sodium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/60D-I

TOXIC EFFECTS :: Endocrine - adrenal cortex hyperplasia Endocrine - changes in adrenal weight Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ug/m3/5H/26W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 330 mg/kg/4H/8W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3751 mg/kg/19W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 945 mg/kg/90D-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 99 mg/kg/3D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 900 mg/kg/26W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Musculoskeletal - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 330 mg/kg/4H/8W-I

TOXIC EFFECTS :: Behavioral - muscle weakness Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 330 mg/m3/4H/8W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 330 mg/m3/4H/8W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 330 mg/m3/4H/8W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Brain and Coverings - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 ppm/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 ppm/4H/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/4H/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3640 mg/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 650 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 650 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 644 mg/kg

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 40 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 80 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 25 ppm/6H

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 32 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 641 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 641 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 641 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,167,1984 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.3 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,79,1987 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,73,1979 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,79,1987 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 22,327,1980 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (45 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,6,1971 OSHA PEL (Construc):8H TWA 20 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 39,1926.55,1994 OSHA PEL (Fed Cont):8H TWA 20 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1045,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm;Skin JAN 1993 OEL-AUSTRALIA:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 2 ppm (4.3 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 2 ppm (4 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 2 ppm (4.5 mg/m3);STEL 4 ppm;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 2 ppm (4.5 mg/m3);STEL 15 ppm;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-INDIA:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 2 ppm (4.3 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 4 ppm (9 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (45 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:TWA 2 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 2 ppm (4.5 mg/m3);STEL 6 ppm;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (4.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 20 ppm (45 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (4 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACRYLONITRILE-air:8H CA TWA 1 ppm;CL 10 ppm/15M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03800 No. of Facilities: 3610 (estimated) No. of Industries: 45 No. of Occupations: 55 No. of Employees: 55698 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03800 No. of Facilities: 2522 (estimated) No. of Industries: 24 No. of Occupations: 39 No. of Employees: 81691 (estimated) No. of Female Employees: 27358 (estimated)

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H350-H370

[ 警示性声明 ]:
P201-P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R23/24/25;R37/38;R41;R43;R45;R51/53

[ 安全声明 (欧洲) ]:
S53-S9-S16-S45-S61-S36/37

[ 危险品运输编码 ]:
UN 1093 3/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
AT5250000

[ 包装等级 ]:
I

[ 危险类别 ]:
3

[ 海关编码 ]:
2926100000

详细合成路线

丙烯腈上游产品

丙烯腈下游产品

1.氰乙醇法环氧乙烷和氢氰酸在水和三甲胺的存在下反应得氰乙醇，然后以碳酸镁为催化剂，于200-280℃脱水制得丙烯腈,收率约75%。此法生产的丙烯腈纯度较高,但氢氰酸毒性大，成本也较高。2.乙炔法乙炔和氢氰酸在氯化亚铜-氯化钾-氯化钠稀盐酸溶液的催化作用下在80-90℃反应得丙烯腈此法生产过程简单，收率良好，以氢氰酸计可达97%。但副反应多，产物精制较难，毒性也大，且原料乙炔价格高于丙烯，在技术和经济上落后于丙烯氨氧化法。1960年以前,该法是世界各国生产丙烯腈的主要方法。3.丙稀氨氧化法以丙烯、氨、空气和水为原料，按其一定量配比进入沸腾床或固定床反应器，在以硅胶作载体的磷钼鉍系或锑铁系催化剂作用下，在400-500℃温度和常压下，生成丙烯腈。然后经中和塔用稀硫酸除去未反应的氨，再经吸收塔用水吸收丙烯腈等气体，形成水溶液，使该水溶液经萃取塔分离乙腈，在脱氢氰酸塔除去氢氰酸，经脱水、精馏而得丙烯腈产品，其单程收率可达75%，副产品有乙腈、氢氰酸和硫铵。此法是目前最有工业生产价值的生产方法。

2.其制备方法主要用丙烯氨氧化法，以丙烯、氨气和空气中的氧气为原料，在催化剂存在下进行反应，催化剂主要是含磷、钼、铋系的化合物，丙烯、氨和空气的摩尔比为1∶(1～1.2)∶(1.8～2.3)，反应温度为400～500℃，反应压力为常压，反应器为流化床。
该反应丙烯腈的单程收率60%～75%。

3.环氧乙烷法　由环氧乙烷和氢氰酸在水和三甲胺的存在下反应制得氰乙醇；然后以碳酸镁为催化剂，于200～280℃脱水制得丙烯腈：

4.乙炔法　由乙炔与氢氰酸作用而得，反应为常压，温度80～90℃，用氯化亚铜和氯化铵为催化剂。该法特点是生产过程简单，但副产物种类较多，不易分离。主反应式如下：

5.丙烯氨氧化法　以丙烯、氨氧和空气中的氧为原料制得，主要副产物为氢氰酸、乙腈、丙烯醛、CO2和CO。主反应如下：

将原料气体以丙烯∶氨∶空气＝1.0∶1.15∶10.5（mol）的比例从底部进入流化床反应器，反应温度440℃，压力63.74kPa。反应热用软水循环回收发生高压蒸汽。反应气体冷却后，洗涤、吸收、精馏后得到高纯度产品。该方法是目前国内外主要的生产方法。

[ 海关编码 ]: 2926100000

[ 中文概述 ]:
2926100000 丙烯腈〔即2-丙烯腈、乙烯基氰〕。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:13.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: X.有毒化学品环境管理放行通知单

[ Summary ]:
2926100000 acrylonitrile。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:6.5%。general tariff:30.0%

Self-cleaning Metal Organic Framework (MOF) based ultra filtration membranes--a solution to bio-fouling in membrane separation processes.

Sci. Rep. 4 , 6555, (2014)

Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment. Current state of the art methods to overcome this are to modify the membranes with eith...

Aptamer-functionalized solid phase microextraction-liquid chromatography/tandem mass spectrometry for selective enrichment and determination of thrombin.

Anal. Chim. Acta 845 , 45-52, (2014)

In this publication, a novel solid phase microextraction (SPME) coating functionalized with a DNA aptamer for selective enrichment of a low abundance protein from diluted human plasma is described. Th...

Double salts of ionic-liquid-based surfactants in microextraction: application of their mixed hemimicelles as novel sorbents in magnetic-assisted micro-dispersive solid-phase extraction for the determination of phenols.

Anal. Bioanal. Chem 407 , 8753-64, (2015)

The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：丙烯腈标准溶液

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥168.0/2ml

联系人：刘佳

产品详情：丙烯腈标准溶液

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：NSC 6362

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1mg ￥需询单/1mg ￥需询单/1mg

联系人：阿拉丁

产品详情：丙烯腈

公司名：山东金悦源新材料有限公司

区域：济南市天桥区

价格：
￥1300.0/160kg ￥8000.0/1ton

联系人：王思兵

产品详情：丙烯腈

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丙烯腈是什么？丙烯腈是用来做什么的?

2019-06-22 21:00:25

丙烯腈是合成纤维，合成橡胶和合成树脂的重要单体。由丙烯腈制得聚丙烯腈纤维即腈纶，其性能极似羊毛，因此也叫合成羊毛。丙烯腈与丁二烯共聚可制得丁腈橡胶，具有良好的耐油性，耐寒性，耐磨性，和电绝缘性能，并且在大多数化学溶剂，阳光和热作用下，性能比较稳定。丙烯腈与丁二烯、苯乙烯共聚制得ABS树脂，具有质轻...

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