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肌氨酸

肌氨酸用途

Sarcosine 1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂。

肌氨酸名称

[ CAS 号 ]:
107-97-1

[ 中文名 ]:
肌氨酸

[ 英文名 ]:
Sarcosine

[中文别名 ]:

[英文别名 ]:

Acide (méthylamino)acétique
SAR
Glycine, N-methyl-
sarcosine zwitterion
MeNHCH2CO2H
MeHNCH2CO2H
EINECS 203-538-6
Methylaminoethanoic acid
N-methyl-Glycine
N-methylaminoacetic acid

肌氨酸生物活性

[ 描述 ]:

Sarcosine 1型甘氨酸转运蛋白 (GlyT) 抑制剂和甘氨酸结合位点的N-甲基-D-天冬氨酸 (NMDA) 受体共激动剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GLYT

信号通路 >> 神经信号通路 >> GLYT

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Zhang HX, et al. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009 Jul 1;587(Pt 13):3207-20.

[相关活性小分子]

肌氨酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
195.1±23.0 °C at 760 mmHg

[ 熔点 ]:
208-212 °C (dec.)(lit.)

[ 分子式 ]:
C₃H₇NO₂

[ 分子量 ]:
89.093

[ 闪点 ]:
71.8±22.6 °C

[ 精确质量 ]:
89.047676

[ PSA ]:
49.33000

[ LogP ]:
-0.79

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C

[ 折射率 ]:
1.431

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
1480 g/L (20 ºC)

肌氨酸MSDS

肌氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VQ2897000

CHEMICAL NAME :: Sarcosine

CAS REGISTRY NUMBER :: 107-97-1

BEILSTEIN REFERENCE NO. :: 1699442

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H7-N-O2

MOLECULAR WEIGHT :: 89.11

肌氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
VQ2897000

[ 海关编码 ]:
29224995

肌氨酸合成路线

肌氨酸上下游产品

肌氨酸上游产品

肌氨酸下游产品

肌氨酸制备

由皂树(Quillaia saponaria)的树皮(韧皮部)，用热水或含水乙醇浸提后加乙醚或丙酮使之沉淀，再经重结晶、精制而得。主要成分为皂苷(皂树皂苷等)。该树主要野生于南美洲智利、玻利维亚等地，中国亦产。

肌氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

肌氨酸文献

Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....

Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

Anal. Sci. 31 , 805-14, (2015)

To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purit...

[Membrane-bound proteases of ompT+ and ompT- Vibrio cholerae strains].

Zh. Mikrobiol. Epidemiol. Immunobiol. (2) , 3-12, (2013)

Detection ofproteases in outer membranes (OM) of ompT+ and ompT- Vibrio cholerae strains of O1 and O139 serogroups.Specific sterile preparations of OM were obtained by lysis of live V. cholerae cells ...

更多文献

肌氨酸