间苯三酚

间苯三酚用途

【用途一】
检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等，测定糠醛、戊糖、多缩戊糖、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的盐酸，骨标本的脱钙。
【用途二】
108-73-6（间苯三酚）是合成黄酮的中间体，还可用于染料催合剂、合成橡胶稳定剂、偶氮复合油墨等的原料。血管扩张药盐酸丁咯地尔 (buflomedil hydrochloride) 的中间体。
【用途三】
间苯三酚（108-73-6）是一种重要的医药中间体和化学通用试剂。广泛用于保健品的合成、织物及皮革的染料稳定剂和抗腐蚀剂、人工造雨替代碘化银、塑料胶囊的生产原料等。此外，在树脂的胶炼和硫化、重氮复印材料、感光复印纸以及照像药品等方面也有许多用途。
【用途四】
检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等。测定戊糖、醛类、木质素、盐酸、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的游离酸（盐酸）。骨标本的脱钙。
【用途五】
检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等。测定戊糖、醛类、木质素、盐酸、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的游离酸（盐酸）。骨标本的脱钙。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

间苯三酚名称

[ CAS 号 ]:
108-73-6

[ 中文名 ]:
间苯三酚

[ 英文名 ]:
Phloroglucinol

[中文别名 ]:

[英文别名 ]:

Compound No: 538
1,3,5-TRIHYDROXYBENZENE
Phloroglucinol
dilospans
Benzene, 1,3,5-trihydroxy-
Dolopax
Reference source: Negwer
sym-Trihydroxybenzene
1,3,5-Benzenetriol
Benzene-s-triol

间苯三酚物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
331.1±12.0 °C at 760 mmHg

[ 熔点 ]:
215-220 °C

[ 分子式 ]:
C₆H₆O₃

[ 分子量 ]:
126.110

[ 闪点 ]:
174.9±14.2 °C

[ 精确质量 ]:
126.031693

[ PSA ]:
60.69000

[ LogP ]:
0.06

[ 外观性状 ]:
白色至淡黄色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.677

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 水溶解性 ]:
水溶性：微溶；可溶于：乙醚,乙醇；微溶：丙酮,苯

间苯三酚MSDS

详细MSDS(安全技术说明书)

间苯三酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY1050000

CHEMICAL NAME :: Phloroglucinol

CAS REGISTRY NUMBER :: 108-73-6

BEILSTEIN REFERENCE NO. :: 1341907

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: QR CQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 991 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 3 gm/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47(2),75,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1900 No. of Facilities: 931 (estimated) No. of Industries: 28 No. of Occupations: 16 No. of Employees: 4964 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1900 No. of Facilities: 82 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 2785 (estimated) No. of Female Employees: 1381 (estimated)

间苯三酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S7-S16-S24/25

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
SY1050000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2907299090

间苯三酚合成路线

详细合成路线

间苯三酚上下游产品

间苯三酚上游产品

间苯三酚下游产品

间苯三酚制备

2，4，6-三硝基苯甲酸用锡粒还原得到2，4，6-三氨基苯甲酸，其稀溶液加热回流20h，用盐酸酸化，冷却结晶，得间苯三酚。收率46-53%。

间苯三酚海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

间苯三酚文献

Influence of different withering conditions on phenolic composition of Avanà, Chatus and Nebbiolo grapes for the production of 'Reinforced' wines.

Food Chem. 194 , 247-56, (2015)

The impact of postharvest withering rates on the phenolic composition of 'reinforced' wines produced with partially dehydrated grapes was evaluated. The study was performed on winegrape varieties with...

Low molecular weight procyanidins from grape seeds enhance the impact of 5-Fluorouracil chemotherapy on Caco-2 human colon cancer cells.

PLoS ONE 9(6) , e98921, (2014)

Grape seed procyanidins (PC) are flavan-3-ol oligomers and polymers known for their biological activity in the gut. Grape seed extract (GSE) have been reported to reduce intestinal injury in a rat mod...

Diazonium modification of porous graphitic carbon with catechol and amide groups for hydrophilic interaction and attenuated reversed phase liquid chromatography.

J. Chromatogr. A. 1422 , 186-93, (2015)

Porous graphitic carbon (PGC) is an increasingly popular and attractive phase for HPLC on account of its chemical and thermal stability, and its unique separation mechanism. However, native PGC is str...

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