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2',5'-二羟基苯乙酮

2',5'-二羟基苯乙酮用途

2,5-Dihydroxyacetophenone 是从熟地黄中分离出的,可通过阻断 ERK1/2 和 NF-κB 信号通路来抑制活化巨噬细胞中炎症介质的产生。

2',5'-二羟基苯乙酮名称

[ CAS 号 ]:
490-78-8

[ 中文名 ]:
2,5-二羟基苯乙酮

[ 英文名 ]:
2,5-Dihydroxyacetophenone

[中文别名 ]:

[英文别名 ]:

Ethanone, 1- (2,5-dihydroxyphenyl)-
2’,5’-Dihydroxyacetophenone
1-(2,5-Dihydroxyphenyl)ethanone
2',5'-Dihydroxyacetophenone
2',5'-Dihydroxy acetophenone
Quinacetophenone
EINECS 207-716-4
2-Acetylhydroquinone
2‘,5‘-Dihydroxyacetophenone
Ethanone, 1-(2,5-dihydroxyphenyl)-

2',5'-二羟基苯乙酮生物活性

[ 描述 ]:

2,5-Dihydroxyacetophenone 是从熟地黄中分离出的,可通过阻断 ERK1/2 和 NF-κB 信号通路来抑制活化巨噬细胞中炎症介质的产生。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> MAPK/ERK信号通路 >> ERK

信号通路 >> 干细胞及 Wnt 通路 >> ERK

[ 靶点 ]

ERK1

ERK2

NF-κB

[体外研究]

2,5-二羟基苯乙酮通过抑制iNOS的表达显著抑制NO的产生,并通过下调LPS刺激RAW264.7细胞的mRNA表达显著降低促炎细胞因子TNF-α和IL-6的水平。2,5-二羟基苯乙酮对LPS刺激细胞胞外信号相关激酶(ERK)1/2的磷酸化和核因子-κB(NF-κB)p65的核移位有明显的抑制作用[1]。

[参考文献]

[1]. Han Y, et al. 2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatoryresponses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food. 2012 Jun;15(6):505-10.

2',5'-二羟基苯乙酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
329.2±27.0 °C at 760 mmHg

[ 熔点 ]:
204-206 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
167.1±20.2 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
1.59

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.595

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

2',5'-二羟基苯乙酮MSDS

2',5'-二羟基苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM7700000

CHEMICAL NAME :: Acetophenone, 2',5'-dihydroxy-

CAS REGISTRY NUMBER :: 490-78-8

BEILSTEIN REFERENCE NO. :: 0637903

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QR CQ BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,140,1953

2',5'-二羟基苯乙酮安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AM7700000

[ 海关编码 ]:
29145000

2',5'-二羟基苯乙酮合成路线

2',5'-二羟基苯乙酮上下游产品

2',5'-二羟基苯乙酮上游产品

2',5'-二羟基苯乙酮下游产品

2',5'-二羟基苯乙酮制备

由对苯二酚二乙酸酯在三氯化铝存在下反应而得。

2',5'-二羟基苯乙酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2',5'-二羟基苯乙酮文献

2,5-Dihydroxyacetophenone: a matrix for highly sensitive matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of proteins using manual and automated preparation techniques Wenzel, Thomas; Sparbier, Katrin; Mieruch, Thorsten; Kostrzewa, Markus

Rapid Commun. Mass Spectrom. 20 , 785-789, (2005)

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