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5-磷酰核糖-1-焦磷酸钠盐

5-磷酰核糖-1-焦磷酸钠盐用途

磷酸核糖焦磷酸(PRPP)五钠是嘌呤和嘧啶核苷酸、氨基酸组氨酸和色氨酸以及辅助因子NAD和NADP生物合成所需的重要代谢物[1]。

5-磷酰核糖-1-焦磷酸钠盐名称

[ CAS 号 ]:
108321-05-7

[ 中文名 ]:
5-磷酰核糖-1-焦磷酸钠盐

[ 英文名 ]:
Phosphoribosyl pyrophosphate pentasodium

[中文别名 ]:

5-磷酸核糖-1-焦磷酸钠盐

[英文别名 ]:

5-Phospho-a-d-ribosyl-diphosphate sodiuM salt
5-PHOSPHO-D-RIBOSE 1-DIPHOSPHAT
P-RIB-PP
5-PHOSPHORYLRIBOSE 1-PYROPHOSPHATE SODIUM SALT
5-PHOSPHO-D-RIBOSE 1-DIPHOSPHATE SODIUM SALT
5-Phospho-D-ribose 1-diphosphate pentasodium salt
PRPP pentasodium salt
5-phosphorylribose 1-pyrophosphate*sodium
P-RIB-PP,PRPP SODIUM SALT

5-磷酰核糖-1-焦磷酸钠盐生物活性

[ 描述 ]:

磷酸核糖焦磷酸(PRPP)五钠是嘌呤和嘧啶核苷酸、氨基酸组氨酸和色氨酸以及辅助因子NAD和NADP生物合成所需的重要代谢物[1]。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

磷酸核糖二磷酸五钠(PRPP)是细胞代谢的重要中间体。PRPP由PRPP合成酶合成,如下所示：核糖5-磷酸+ATP→ PRPP+放大器。PRPP广泛存在于生物体内,用于糖苷键形成的取代反应。PRPP被用于嘌呤和嘧啶核苷酸、氨基酸组氨酸和色氨酸、辅因子NAD和四氢甲基蝶呤、阿拉伯糖基单磷酸癸烯醇和某些氨基糖苷类抗生素的生物合成[1]。磷酸核糖基二磷酸(5-磷酸核糖基-l-焦磷酸)五钠是腺嘌呤磷酸核糖基转移酶和次黄嘌呤鸟嘌呤磷酸核糖基转移酶共有的底物,在缺乏次黄嘌呤鸟嘌呤磷酸核糖基转移酶的人红细胞中积累。添加到纯化腺嘌呤磷酸核糖转移酶中的5-磷酸核糖-l-焦磷酸盐可使其稳定,防止热失活[2]。

[参考文献]

[1]. Schneiter R, et al. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p. Microbiology (Reading). 2000;146 Pt 12:3269-3278.

[2]. Greene ML, et al. Substrate stabilization: genetically controlled reciprocal relationship of two human enzymes. Science. 1970;167(3919):887-889.

5-磷酰核糖-1-焦磷酸钠盐物理化学性质

[ 分子式 ]:
C₅H₈Na₅O₁₄P₃

[ 分子量 ]:
499.98

[ 精确质量 ]:
477.879608

[ PSA ]:
270.49000

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless to very faintly yellow

5-磷酰核糖-1-焦磷酸钠盐安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H371

[ 警示性声明 ]:
P260

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-68/20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

5-磷酰核糖-1-焦磷酸钠盐文献

Relation between muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells.

J. Physiol. 441 , 477-99, (1991)

1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emissi...

Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Bioorg. Med. Chem. Lett. 8 , 1643-8, (1998)

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzy...

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