1-氯丁烷

1-氯丁烷用途

【用途一】
用于油脂、橡胶、天然树脂溶剂、医药中间体、助催化剂等
【用途二】
用作溶剂，也用于有机合成
【用途三】
用作溶剂及有机合成中丁基化试剂，还可用于制造丁基纤维素、驱虫剂及赛璐珞、保泰松等
【用途四】
1-氯正丁烷是制备杀菌剂腈菌唑和咪菌唑的原料。
【用途五】
在医药工业中，用作合成动物驱虫剂和保泰松药物的原料，在有机合成中，用作合成月桂酸二丁基铝、丁基纤维素等的原料。另外，还用作乙烯聚合催化剂的助剂，脱蜡剂及其他有机合成等。
【用途六】
109-69-3（1-氯丁烷）用于制备烯烃聚合催化剂——丁基锂，格氏反应：制备丁基锡类产品，1-氯丁烷（109-69-3）在医药制备保泰松，农药方面：制备杀虫剂腈菌唑等聚醚生产作溶剂
【用途七】
有机合成。制备丁基纤维素的丁基化剂。溶剂。

1-氯丁烷名称

[ CAS 号 ]:
109-69-3

[ 中文名 ]:
1-氯丁烷

[ 英文名 ]:
1-Chlorobutane

[中文别名 ]:

[英文别名 ]:

1-chloroethane
EINECS 203-696-6
Sure Shot
MFCD00001009
Butyl Chloride
1-butyl chloride
Chlorobutane,1
Chlorure de butyle
NBC wormer
N-BUTYL CHLORIDE

1-氯丁烷物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
78.2±3.0 °C at 760 mmHg

[ 熔点 ]:
-123ºC

[ 分子式 ]:
C₄H₉Cl

[ 分子量 ]:
92.567

[ 闪点 ]:
-6.7±0.0 °C

[ 精确质量 ]:
92.039276

[ LogP ]:
2.56

[ 外观性状 ]:
水白色液体带有一种强烈的气味

[ 蒸汽密度 ]:
3.2 (vs air)

[ 蒸汽压 ]:
103.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.396

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable. Note low flash point and wide explosion limit range. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
0.5 g/L (20 ºC)

1-氯丁烷MSDS

详细MSDS(安全技术说明书)

1-氯丁烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ6300000

CHEMICAL NAME :: Butane, 1-chloro-

CAS REGISTRY NUMBER :: 109-69-3

BEILSTEIN REFERENCE NO. :: 1730909

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C4-H9-Cl

MOLECULAR WEIGHT :: 92.58

WISWESSER LINE NOTATION :: G4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2670 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 mg/kg/26W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10500 mg/kg/14D-I

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13927 mg/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 500 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-312,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3168 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 3202 (estimated) No. of Female Employees: 880 (estimated)

1-氯丁烷安全信息

[ 符号 ]:

GHS02, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H412

[ 警示性声明 ]:
P210-P273-P301 + P310-P331-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S16-S29-S9

[ 危险品运输编码 ]:
UN 1127

[ WGK德国 ]:
2

[ RTECS号 ]:
EJ6300000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.0

[ 海关编码 ]:
2903299090

1-氯丁烷合成路线

详细合成路线

1-氯丁烷上下游产品

1-氯丁烷上游产品

1-氯丁烷下游产品

1-氯丁烷制备

1.由正丁醇与氯化氢反应而得：正丁醇和浓盐酸在氯化锌存在下加热回流反应，将反应物用水洗涤、干燥，分馏，收集75-78.5℃馏分即为成品。原料消耗定额：正丁醇（95%）1600kg/t、盐酸（30%）2780kg/t。

2.其制备方法是将丁醇与氯化氢在催化剂ZnCl₂存在下进行反应，反应结束后洗涤、干燥、分馏得产品。反应方程式：

3.由正丁醇与浓盐酸在无水氯化锌存在下共热而制得。

4.制法：

于3L反应瓶中，加入浓盐酸860mL，冷却下分批加入无水氯化锌1363g(10mol),摇动，以使氯化锌尽量溶解。加入正丁醇(2)371g（5mol）和几粒沸石。安装竖直向上的回流冷凝器，其顶端蒸馏装置，接受瓶用一只弯管连到气体吸收瓶，以吸收逸出的氯化氢气体。将油浴温度加热到150℃，溶液开始沸腾，并由1-氯丁烷蒸出。控制竖直向上的回流冷凝器的水的流速，使冷凝器的温度保持在75～80℃。待蒸出较慢时可缓慢提高浴温至165℃左右，直至基本无馏除外。馏出物依次用100mL冷水、50mL冷的浓硫酸(分四次)、水、10%的碳酸钠溶液洗涤，无水氯化钙干燥，蒸馏，收集75.5～77.5℃的馏分，得1-氯丁烷(1)355g,收率76%。

1-氯丁烷海关

[ 海关编码 ]: 2903199000

[ 中文概述 ]:
2903199000 其他无环烃的饱和氯化衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1-氯丁烷文献

Nefopam Hydrochloride: A Fatal Overdose.

J. Anal. Toxicol. 39 , 486-9, (2015)

Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and ...

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine.

Drug Test. Anal. 6(6) , 506-15, (2014)

The classic approach of controlled volunteer studies to study drug metabolism is difficult or impossible to undertake for novel psychoactive substances (NPS), as there is generally very limited inform...

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