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2-甲胺乙醇

2-甲胺乙醇用途

【用途一】
用作医药、有机合成中间体

2-甲胺乙醇名称

[ CAS 号 ]:
109-83-1

[ 中文名 ]:
N-甲基-2-羟基乙胺

[ 英文名 ]:
2-Methylaminoethanol

[中文别名 ]:

[英文别名 ]:

MFCD00002839
2-Hydroxypropanamine
2-(Methylamino)ethanol
(RS)-1-Amino-2-hydroxypropane
1-Amino-2-hydroxypropane
propan-2-ol, 1-amino-
N-Methylethanolamine
2-Methylaminoethanol
(±)-1-Amino-2-propanol
1-Aminopropan-2-ol

2-甲胺乙醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
159.9±13.0 °C at 760 mmHg

[ 熔点 ]:
-3 °C

[ 分子式 ]:
C₃H₉NO

[ 分子量 ]:
75.110

[ 闪点 ]:
73.9±0.0 °C

[ 精确质量 ]:
75.068413

[ PSA ]:
32.26000

[ LogP ]:
-0.96

[ 外观性状 ]:
无色液体,无悬浮物

[ 蒸汽密度 ]:
2.6 (vs air)

[ 蒸汽压 ]:
0.9±0.6 mmHg at 25°C

[ 折射率 ]:
1.440

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with oxidizing agents.

[ 水溶解性 ]:
miscible

2-甲胺乙醇MSDS

2-甲胺乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL6650000

CHEMICAL NAME :: Ethanol, 2-(methylamino)-

CAS REGISTRY NUMBER :: 109-83-1

BEILSTEIN REFERENCE NO. :: 1071196

LAST UPDATED :: 199806

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C3-H9-N-O

MOLECULAR WEIGHT :: 75.13

WISWESSER LINE NOTATION :: Q2M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/20/1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 10,61,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1802 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 225,428,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1070 uL/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536158 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4016 No. of Facilities: 7733 (estimated) No. of Industries: 36 No. of Occupations: 28 No. of Employees: 39013 (estimated) No. of Female Employees: 11887 (estimated)

2-甲胺乙醇安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312-H314-H335-H373

[ 警示性声明 ]:
P280-P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 靶器官 ]:
Epididymus, Kidney, Liver, Testes, ovary, spleen

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R21/22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
KL6650000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29221980

2-甲胺乙醇合成路线

2-甲胺乙醇上下游产品

2-甲胺乙醇上游产品

2-甲胺乙醇下游产品

2-甲胺乙醇海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-甲胺乙醇文献

Enzymatic properties and substrate specificity of a bacterial phosphatidylcholine synthase.

FEBS J. 281(15) , 3523-41, (2014)

Phosphatidylcholine (PC) is a rare membrane lipid in bacteria, but is crucial for virulence of the plant pathogen Agrobacterium tumefaciens and various other pathogens. Agrobacterium tumefaciens uses ...

Acute toxicity and primary irritancy of alkylalkanolamines.

Vet. Hum. Toxicol. 38(6) , 422-6, (1996)

The acute handling hazards of several alkylalkanolamines were determined by investigating their potential acute toxicity and primary irritancy. Materials studied were N-methylethanolamine (MEA), N, N,...

Recovery of choline oxidase activity by in vitro recombination of individual segments.

Appl. Microbiol. Biotechnol. 81(2) , 275-82, (2008)

Initial attempts to express a choline oxidase from Arthrobacter pascens (APChO-syn) in Escherichia coli starting from a synthetic gene only led to inactive protein. However, activity was regained by t...

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