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胍西定

胍西定用途

Guancydine (Guancidine) 是一种抗高血压剂。

胍西定名称

[ CAS 号 ]:
1113-10-6

[ 中文名 ]:
胍西定

[ 英文名 ]:
Guancydine

[英文别名 ]:

tert.-Amyldicyandiamid
Guancydine
EINECS 263-799-7
EINECS 214-198-3
Guancidine
1-Cyano-3-t-pentylguanidine
Guancydine [USAN]
Guancidinum [INN-Latin]
1-Cyano-3-tert-amylguanidine
Guancidina [INN-Spanish]

胍西定生物活性

[ 描述 ]:

Guancydine (Guancidine) 是一种抗高血压剂。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Clark DW, et al. Guancydine: a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol. Ann Intern Med. 1972 Apr;76(4):579-85.

胍西定物理化学性质

[ 密度 ]:
1.02g/cm3

[ 沸点 ]:
239.3ºC at 760 mmHg

[ 分子式 ]:
C₇H₁₄N₄

[ 分子量 ]:
154.21

[ 闪点 ]:
98.5ºC

[ 精确质量 ]:
154.12200

[ PSA ]:
71.70000

[ LogP ]:
1.65158

[ 蒸汽压 ]:
0.0404mmHg at 25°C

[ 折射率 ]:
1.504

[ 储存条件 ]:
-20°C，密闭，干燥

胍西定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF0175000

CHEMICAL NAME :: Guanidine, 1-cyano-3-tert-pentyl-

CAS REGISTRY NUMBER :: 1113-10-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H14-N4

MOLECULAR WEIGHT :: 154.25

WISWESSER LINE NOTATION :: NCMYUM&MX2&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 313 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 322 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 161,88,1968

胍西定安全信息

[ 海关编码 ]:
2926909090

胍西定海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

胍西定