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十一酸

十一酸用途

Undecanoic acid (Undecanoate) 是一种具有抗真菌作用的一元羧酸,它能抑制红毛癣菌细胞外角朊酶、脂肪酶的产生和多种磷脂的生物合成。

十一酸名称

[ CAS 号 ]:
112-37-8

[ 中文名 ]:
十一烷酸

[ 英文名 ]:
Undecanoic acid

[中文别名 ]:

[英文别名 ]:

n-undecylic acid
n-undecanoic acid
Undecanoic acid
Hendecanoic Acid
MFCD00002730
Undecylic acid
EINECS 203-964-2
1-Decanecarboxylic acid

十一酸生物活性

[ 描述 ]:

Undecanoic acid (Undecanoate) 是一种具有抗真菌作用的一元羧酸,它能抑制红毛癣菌细胞外角朊酶、脂肪酶的产生和多种磷脂的生物合成。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Hornung B, et al. Medium chain length fatty acids stimulate triacylglycerol synthesis in tissue culture cells. Biochem Pharmacol. 1992 Jan 22;43(2):175-81.

[2]. Das SK, et al. Effect of undecanoic acid on phospholipid metabolism in Trichophyton rubrum. Sabouraudia. 1982 Dec;20(4):267-72.

[3]. Das SK, et al. Effect of undecanoic acid on the production of exocellular lipolytic and keratinolytic enzymes by undecanoic acid-sensitive and -resistant strains of Trichophyton rubrum. Sabouraudia. 1982 Sep;20(3):179-84.

[4]. Coppa M, et al. Effect of a hay-based diet or different upland grazing systems on milk volatile compounds. J Agric Food Chem. 2011 May 11;59(9):4947-54.

十一酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
283.3±3.0 °C at 760 mmHg

[ 熔点 ]:
28-31 °C(lit.)

[ 分子式 ]:
C₁₁H₂₂O₂

[ 分子量 ]:
186.291

[ 闪点 ]:
128.2±11.9 °C

[ 精确质量 ]:
186.161987

[ PSA ]:
37.30000

[ LogP ]:
4.50

[ 外观性状 ]:
无色至淡黄色液体或固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.446

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
insoluble

十一酸MSDS

十一酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ2275000

CHEMICAL NAME :: Undecanoic acid

CAS REGISTRY NUMBER :: 112-37-8

BEILSTEIN REFERENCE NO. :: 1759287

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H22-O2

MOLECULAR WEIGHT :: 186.33

WISWESSER LINE NOTATION :: QV10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,369,1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961

十一酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
YQ2275000

[ 海关编码 ]:
29159080

十一酸合成路线

十一酸上下游产品

十一酸上游产品

十一酸下游产品

十一酸制备

1. 烟草：OR，26；FC，9， 15， 18， 40。

十一酸海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

十一酸文献

Use of multivariate statistical techniques to optimize the separation of 17 capsinoids by ultra performance liquid chromatography using different columns.

Talanta 134 , 256-63, (2015)

In this work a multivariate statistical tool (Derringer and Suich optimization) was proposed for the separation of seventeen capsinoids (natural and synthetic) using the UHPLC-DAD chromatography. Caps...

Direct Derivatization vs Aqueous Extraction Methods of Fecal Free Fatty Acids for GC-MS Analysis.

Lipids 50 , 681-9, (2015)

A comprehensive and accurate determination of free fatty acids (FFA) is required for fecal metabolomic investigations. The present study compares three aqueous extraction methods (1) ULTRA-TURRAX(®), ...

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo...

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十一酸