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十四醇

十四醇用途

从肉豆蔻中分离得到的1-十四醇是一种直链饱和脂肪醇。1-十四醇具有抗菌和抗炎(牙周炎)活性[1]。

十四醇名称

[ CAS 号 ]:
112-72-1

[ 中文名 ]:
1-十四醇

[ 英文名 ]:
1-Tetradecanol

[中文别名 ]:

[英文别名 ]:

teradecyl alcohol
Myristic alcohol
n-Tetradecyl alcohol
Tetradecyl alcohol
1-Tetradecanol
n-tetradecyl acrylate
Myristyl alcohol
n-Tetradecanol
Nacol 14-95
Acrylsaeure-tetradecylester

十四醇生物活性

[ 描述 ]:

从肉豆蔻中分离得到的1-十四醇是一种直链饱和脂肪醇。1-十四醇具有抗菌和抗炎(牙周炎)活性[1]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. XiaoyeGeng, et al. Design and fabrication of reversible thermochromic microencapsulated phase change materials for thermal energy storage and its antibacterial activity. Energy. Volume 159, 15 September 2018, Pages 857-869.

十四醇物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
263.2±0.0 °C at 760 mmHg

[ 熔点 ]:
35-39 °C(lit.)

[ 分子式 ]:
C₁₄H₃₀O

[ 分子量 ]:
214.387

[ 闪点 ]:
125.9±4.6 °C

[ 精确质量 ]:
214.229660

[ PSA ]:
20.23000

[ LogP ]:
6.19

[ 外观性状 ]:
白色固体

[ 蒸汽密度 ]:
7.4 (vs air)

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.445

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
insoluble

十四醇MSDS

十四醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XB8655000

CHEMICAL NAME :: 1-Tetradecanol

CAS REGISTRY NUMBER :: 112-72-1

BEILSTEIN REFERENCE NO. :: 1742652

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H30-O

MOLECULAR WEIGHT :: 214.44

WISWESSER LINE NOTATION :: Q14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,699,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,699,1975 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg/24W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,70,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83128 No. of Facilities: 336 (estimated) No. of Industries: 7 No. of Occupations: 16 No. of Employees: 22755 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83128 No. of Facilities: 136 (estimated) No. of Industries: 5 No. of Occupations: 20 No. of Employees: 4525 (estimated) No. of Female Employees: 1820 (estimated)

十四醇安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H410

[ 警示性声明 ]:
P273-P305 + P351 + P338-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
-

[ RTECS号 ]:
XB8655000

[ 海关编码 ]:
2905199090

十四醇合成路线

十四醇上下游产品

十四醇上游产品

十四醇下游产品

十四醇制备

由椰子油经甲酯化、高压加氢得到的混合醇，再经分馏精制得产品。亦可用齐格勒法乙烯齐聚、氧化、水解制取。

可从鲸蜡、鲸油中单离或用其相应的酸、酯催化还原得到，视工业生产的条件与价格考虑应用的高压加氢法还是氢化锂铝氢化还原法。

十四醇海关

[ 海关编码 ]: 2905199090

[ 中文概述 ]:
2905199090. 其他饱和一元醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905199090. saturated monohydric alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

十四醇文献

Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods.

Food Chem. 194 , 749-57, (2015)

Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natura...

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography.

J. Chromatogr. A. 1392 , 82-90, (2015)

Low thermal mass gas chromatography (LTM-GC) was evaluated for rapid, high peak capacity separations with three injection methods: liquid, headspace solid phase micro-extraction (HS-SPME), and direct ...

Fast and slow interactions of n-alkanols with human 5-HT3A receptors: Implications for anesthetic mechanisms.

Biochim. Biophys. Acta 1848 , 1524-35, (2015)

This is part of a continuing patch-clamp study exploring molecular actions of anesthetics and systematically varied related substances on 5-HT3A receptors as prototypes of ligand-gated ion channels. S...

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十四醇