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吡啶硫酮

吡啶硫酮用途

Pyrithione 是具有抗菌和抗真菌活性的化合物。

吡啶硫酮名称

[ CAS 号 ]:
1121-30-8

[ 中文名 ]:
1-氧化-2-巯基吡啶

[ 英文名 ]:
Pyrithione

[中文别名 ]:

[英文别名 ]:

1-hydroxy-2-pyridinethione
2-PYRIDINETHIONE,1-HYDROXY
N-HYDROXYPYRIDINE-2-THIONE
PTO
1-hydroxypyridine-2-thione
N-hydroxy-2-pyridinethione
EINECS 214-328-9
1-hydroxyl-1H-pyridine-2-thione
SQ-2113

吡啶硫酮生物活性

[ 描述 ]:

Pyrithione 是具有抗菌和抗真菌活性的化合物。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. PANSY FE, et al. In vitro studies with 1-hydroxy-2(1H) pyridinethione. Proc Soc Exp Biol Med. 1953 Jan;82(1):122-4.

吡啶硫酮物理化学性质

[ 密度 ]:
1.43g/cm3

[ 沸点 ]:
253.8ºC at 760mmHg

[ 分子式 ]:
C₅H₅NOS

[ 分子量 ]:
127.16400

[ 闪点 ]:
107.3ºC

[ 精确质量 ]:
127.00900

[ PSA ]:
57.25000

[ LogP ]:
1.45490

[ 蒸汽压 ]:
0.00275mmHg at 25°C

[ 折射率 ]:
1.732

[ 储存条件 ]:
2-8℃

吡啶硫酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT9625000

CHEMICAL NAME :: 2-(1H)-Pyridinethione, 1-hydroxy-

CAS REGISTRY NUMBER :: 1121-30-8

BEILSTEIN REFERENCE NO. :: 0109936

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H5-N-O-S

MOLECULAR WEIGHT :: 127.17

WISWESSER LINE NOTATION :: T6NYJ AQ BUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 535 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,156,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,156,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,156,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,156,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued. Volume(issue)/page/year: 3,1,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

吡啶硫酮安全信息

[ 海关编码 ]:
2933399090

吡啶硫酮合成路线

详细合成路线

吡啶硫酮海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%