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4-硝基吡啶-N-氧化物

4-硝基吡啶-N-氧化物用途

用作合成中间体。

4-硝基吡啶-N-氧化物名称

[ CAS 号 ]:
1124-33-0

[ 中文名 ]:
4-硝基吡啶-N-氧化物

[ 英文名 ]:
4-Nitropyridine N-oxide

[中文别名 ]:

[英文别名 ]:

4-Nitropyridine N-ox
4-Nitropyridine oxide
4-NITRO-N-OXOPYRIDINE
4-nitraminopyridine N-oxide
wellno604aa
Avitrol 100
4-Nitropyridine N-Oxide
MFCD00006206
4-nitropyridine-N-oxide
4-Nitropyridine 1-oxide

4-硝基吡啶-N-氧化物物理化学性质

[ 密度 ]:
1.43 g/cm3

[ 沸点 ]:
397.2ºC at 760 mmHg

[ 熔点 ]:
159-162 °C(lit.)

[ 分子式 ]:
C₅H₄N₂O₃

[ 分子量 ]:
140.09700

[ 闪点 ]:
194ºC

[ 精确质量 ]:
140.02200

[ PSA ]:
71.28000

[ LogP ]:
1.54650

[ 外观性状 ]:
白色至淡黄色晶体

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

4-硝基吡啶-N-氧化物MSDS

4-硝基吡啶-N-氧化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6380000

CHEMICAL NAME :: Pyridine, 4-nitro-, 1-oxide

CAS REGISTRY NUMBER :: 1124-33-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C5-H4-N2-O3

MOLECULAR WEIGHT :: 140.11

WISWESSER LINE NOTATION :: T6NJ AO DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3916 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 7208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg/15W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Cells - not otherwise specified

DOSE/DURATION :: 50 umol/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971

4-硝基吡啶-N-氧化物安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S45-S37/39-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
UT6380000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29333999

4-硝基吡啶-N-氧化物合成路线

4-硝基吡啶-N-氧化物上下游产品

4-硝基吡啶-N-氧化物上游产品

4-硝基吡啶-N-氧化物下游产品

4-硝基吡啶-N-氧化物制备

在过氧化氢的碱溶液中加热，得到4-羟基吡啶-N-氧化物。用吡啶-N-氧化物与发烟硝酸和硫酸混合酸作用制取

4-硝基吡啶-N-氧化物海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-硝基吡啶-N-氧化物文献

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.

PLoS ONE 8(12) , e83564, (2013)

N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of ...

Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents.

Org. Lett. 13(22) , 6102-5, (2011)

Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurre...

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