氨磷汀

氨磷汀用途

Amifostine trihydrate (WR2721 trihydrate) 是一种广谱细胞保护剂和辐射防护剂。Amifostine trihydrate 可选择性保护正常组织免受放射线和化学疗法造成的损害。Amifostine trihydrate 是有效的 HIF-α1 和 p53 诱导剂。Amifostine trihydrate 通过清除氧衍生的自由基来保护细胞免受损伤。Amifostine trihydrate 可降低肾脏毒性并具有抗血管生成作用。

氨磷汀名称

[ CAS 号 ]:
112901-68-5

[ 中文名 ]:
氨磷汀

[ 英文名 ]:
Amifostine trihydrate

[中文别名 ]:

[英文别名 ]:

MFCD00233058
UNII-M487QF2F4V
WR-2721
Anifostine trihydrate
Amifostine
Amifostine trihydrate

氨磷汀生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> MDM-2/p53

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

[参考文献]

[1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

[2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

[3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.

[4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.

[5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

氨磷汀物理化学性质

[ 密度 ]:
1.367g/cm3

[ 沸点 ]:
441.7ºC at 760 mmHg

[ 分子式 ]:
C₅H₂₁N₂O₆PS

[ 分子量 ]:
268.269

[ 闪点 ]:
220.9ºC

[ 精确质量 ]:
268.085785

[ PSA ]:
158.38000

[ LogP ]:
0.64900

[ 外观性状 ]:
powder

[ 蒸汽压 ]:
4.9E-09mmHg at 25°C

[ 储存条件 ]:
2-8°C

氨磷汀MSDS

详细MSDS(安全技术说明书)

氨磷汀安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TE6491000

[ 海关编码 ]:
2930909090

氨磷汀海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氨磷汀文献

The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.

In Vivo 26(6) , 889-97, (2012)

Use of zebrafish models may decrease the cost of screening new irradiation protectors and mitigators.Zebrafish (Danio rerio) models were tested for screening water-soluble radiation protectors and mit...

A Phase I Clinical and Pharmacology Study Using Amifostine as a Radioprotector in Dose-escalated Whole Liver Radiation Therapy

Int. J. Radiat. Oncol. Biol. Phys. 83(5) , 1441-7, (2012)

Purpose Diffuse intrahepatic tumors are difficult to control. Whole-liver radiotherapy has been limited by toxicity, most notably radiation-induced liver disease. Amifostine is a prodrug free-radical ...

The effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritis.

Eur. Rev. Med. Pharmacol. Sci. 17(10) , 1351-9, (2013)

Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It...

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氨磷汀