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5-氨基-3-甲基-1-苯基吡唑

5-氨基-3-甲基-1-苯基吡唑用途

【用途一】
用作染料和医药的中间体

5-氨基-3-甲基-1-苯基吡唑名称

[ CAS 号 ]:
1131-18-6

[ 中文名 ]:
5-氨基-3-甲基-1-苯基吡唑

[ 英文名 ]:
3-Methyl-1-phenyl-1H-pyrazol-5-amine

[中文别名 ]:

[英文别名 ]:

5-methyl-2-phenylpyrazol-3-amine
1H-Pyrazol-5-amine, 3-methyl-1-phenyl-
5-AMINO-3-METHYL-1-PHENYLPYRAZOLE
MFCD00020727
T5NNJ AR& C1 EZ
3-Methyl-1-phenyl-1H-pyrazol-5-amine
EINECS 214-463-3

5-氨基-3-甲基-1-苯基吡唑物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
333.0±22.0 °C at 760 mmHg

[ 熔点 ]:
114-117 °C(lit.)

[ 分子式 ]:
C₁₀H₁₁N₃

[ 分子量 ]:
173.214

[ 闪点 ]:
155.2±22.3 °C

[ 精确质量 ]:
173.095291

[ PSA ]:
43.84000

[ LogP ]:
1.96

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
室温，密封，干燥

5-氨基-3-甲基-1-苯基吡唑MSDS

详细MSDS(安全技术说明书)

5-氨基-3-甲基-1-苯基吡唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4990000

CHEMICAL NAME :: 1H-Pyrazole-5-amine, 3-methyl-1-phenyl-

CAS REGISTRY NUMBER :: 1131-18-6

BEILSTEIN REFERENCE NO. :: 0140666

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H11-N3

MOLECULAR WEIGHT :: 173.24

WISWESSER LINE NOTATION :: T5NNJ AR& C1 EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay)

REFERENCE :: LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 27,295,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

REFERENCE :: LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

5-氨基-3-甲基-1-苯基吡唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ4990000

[ 海关编码 ]:
2933199090

5-氨基-3-甲基-1-苯基吡唑合成路线

详细合成路线

5-氨基-3-甲基-1-苯基吡唑上下游产品

5-氨基-3-甲基-1-苯基吡唑上游产品

5-氨基-3-甲基-1-苯基吡唑下游产品

5-氨基-3-甲基-1-苯基吡唑海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氨基-3-甲基-1-苯基吡唑文献

Synthesis of Newly Substituted Pyrazoles and Substituted Pyrazolo [3, 4-b] Pyridines Based on 5-Amino-3-Methyl-1-Phenylpyrazole. El-Emary TI.

J. Chin. Chem. Soc. 54(2) , 507-518, (2007)

An unexpected chemical behavior of 5-N-(benzotriazol-1-ylmethyl) amino-3-tert-butyl-1-phenylpyrazole. Abonia R, et al.

Tetrahedron Lett. 43(22) , 5617-5620, (2002)

The synthesis of fused and pendant pyrazole heterocyclic compounds from 5-amino-3-methyl-1-phenylpyrazole and their evaluation as fluorescent brightening agents. Tagdiwala PV and Rangnekar DW.

J. Chem. Technol. Biotechnol. 38(2) , 77-84, (1987)

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