苯肼

苯肼用途

【用途一】
用于制染料、药物、显影剂等
【用途二】
用作分析试剂及色谱分析试剂
【用途三】
苯肼在农药生产上用于合成有机磷杀虫剂三唑磷的中间体1-苯基氨基脲、哒嗪硫磷的中间体1-苯基-3，6-二羟基哒嗪，也是杀菌剂新品种噁唑菌酮(famoxadone)、咪唑菌酮(fenamidone)的中间体，此外，苯肼作为一种有机合成原料，也用作染料、医药等行业的中间体，还用作分析试剂。
【用途四】
该品是染料、医药、农药的中间体，用于生产色酚AS-G、药物安替比林等。将苯肼溶于95%乙醇中，然后加入苯甲醛，回流1h可得苯腙。苯腙也是有机合成中间体。苯肼也用作分析试剂。
【用途五】
作为弱碱用于使铅、铬和其他三价、四价元素以氢氧化物形式沉淀出来。光度测定铝、铬、铜、钼、钛、锆。检定金、铱、钼、钯、铂、银。比色测定磷酸的还原剂。可与醛、酮、糖形成熔点不同的苯腙，据以鉴别这些物质。

苯肼名称

[ CAS 号 ]:
100-63-0

[ 中文名 ]:
苯肼

[ 英文名 ]:
Phenylhydrazine

[中文别名 ]:

肼基苯

[英文别名 ]:

Fenilidrazina [Italian]
EINECS 202-873-5
Hydrazine,phenyl
Fenylhydrazine [Dutch]
Hydrazinobenzene
Hydrazine-benzene
Phenylhydrazine
MFCD00007573
Phenylhydrazin
N-phenyl hydrazine

苯肼物理化学性质

[ 密度 ]:
1.099 g/mL at 25 °C(lit.)

[ 沸点 ]:
238-241 °C(lit.)

[ 熔点 ]:
19 °C

[ 分子式 ]:
C₆H₈N₂

[ 分子量 ]:
108.14100

[ 闪点 ]:
89 ºC

[ 精确质量 ]:
108.06900

[ PSA ]:
38.05000

[ LogP ]:
1.74550

[ 外观性状 ]:
黄色至淡棕色油性液体

[ 蒸汽密度 ]:
4.3 (vs air)

[ 蒸汽压 ]:
<0.1 mm Hg ( 20 °C)

[ 折射率 ]:
n20/D 1.607(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 稳定性 ]:
Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides.

[ 水溶解性 ]:
145 g/L (20 ºC)

苯肼MSDS

详细MSDS(安全技术说明书)

苯肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV8925000

CHEMICAL NAME :: Hydrazine, phenyl-

CAS REGISTRY NUMBER :: 100-63-0

BEILSTEIN REFERENCE NO. :: 0606080

LAST UPDATED :: 199806

DATA ITEMS CITED :: 48

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: ZMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2610 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2120 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg/7D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1469,1981 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (22 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,207,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 5 ppm (22 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENYLHYDRAZINE-air:CA CL 0.14 ppm/120M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 57300 No. of Facilities: 56 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1120 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 57300 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 212 (estimated) No. of Female Employees: 19 (estimated)

苯肼安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H315-H317-H319-H331-H341-H350-H372-H400

[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/24/25;R36/38;R43;R45;R48/23/24/25;R50;R68

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 2572 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
MV8925000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2928000090

苯肼合成路线

详细合成路线

苯肼上下游产品

苯肼上游产品

苯肼下游产品

苯肼制备

1.由氯化重氮苯经还原而制得。

2.将苯胺与30%的盐酸水溶液以1∶2的摩尔比混合，冷至2℃，并控制温度在0～5℃下慢慢加入6mol／l的亚硝酸钠溶液至淀粉碘化钾试纸变蓝，继续搅拌30min，得重氮盐溶液，备用。在10～15℃下，用浓氢氧化钠将40%的亚硫酸氢钠溶液调至ph值6～7，并冷至0～5℃，搅拌下将上述重氮盐快速加入，之后，继续搅拌15min，当ph 值为6～7时，再升温至70～80℃，并慢慢将浓盐酸用导管通到反应液面以下，加完后恒温1～2h，冷至20℃以下，滤出的结晶即为苯肼盐酸盐。将所得苯肼盐酸盐用少量水溶解，加活性炭脱色，过滤后的滤液加入过量氢氧化钠溶液，冷却至15～20℃用苯或乙醚提取数次，合并提取液，并加入无水碳酸钾干燥，再进行苯或乙醚的回收，所得苯肼粗品在2399Pa下蒸馏，收集137～138℃馏分，即为纯品苯肼。过程反应如下：

苯肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

苯肼文献

Factors affecting formulation characteristics and stability of ascorbic acid in water-in-oil creams.

Int. J. Cosmet. Sci. 36(5) , 494-504, (2014)

The present investigation is based on the formulation of water-in-oil (w/o) cream preparations of ascorbic acid (AA) at pH 4-6 using different emollients and humectants.The preparations were stored in...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

3D intra-stacked CoO/carbon nanocomposites welded by Ag nanoparticles for high-capacity, reversible lithium storage.

Nanoscale 7 , 10368-76, (2015)

A wet-chemical, facile strategy is proposed for forming three-dimensional intra-structured nanocomposites to facilitate the development of high performance anodes for lithium ion batteries. The nanoco...

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苯肼