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N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐

用途

E-4031是抗心律失常剂苯磺酰胺，阻断ATP敏感性钾通道。

名称

[ CAS 号 ]:
113559-13-0

[ 中文名 ]:
N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐

[ 英文名 ]:
E-4031

[英文别名 ]:

E-4031
MFCD01754739
E 4031 dihydrochloride
PDZ1 Domain inhibitor peptide

生物活性

[ 描述 ]:

E-4031是抗心律失常剂苯磺酰胺,阻断ATP敏感性钾通道。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Nalos L, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol. 2012 Jan;165(2):467-78.

[2]. Verheijck EE, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.

[3]. Izumi-Nakaseko H, et al. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2014 Oct 5;740:263-70.

[4]. Izumi D, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9.

[相关活性小分子]

物理化学性质

[ 沸点 ]:
561.7ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₂₉Cl₂N₃O₃S

[ 分子量 ]:
474.444

[ 闪点 ]:
293.5ºC

[ 精确质量 ]:
473.130676

[ PSA ]:
87.75000

[ LogP ]:
5.59460

[ 蒸汽压 ]:
1.21E-12mmHg at 25°C

[ 储存条件 ]:
2-8℃

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

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