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石竹素

石竹素用途

Caryophyllene oxide 是从 Annona squamosa L. bark. 中分离得到的,具有镇痛和抗炎活性。

石竹素名称

[ CAS 号 ]:
1139-30-6

[ 中文名 ]:
石竹素

[ 英文名 ]:
Caryophyllene oxide

[中文别名 ]:

[英文别名 ]:

(-)-b-Caryophyllene oxide
6,7-Epoxy-3(15)-caryophyllene
(−)-Caryophyllene oxide
4b,5a-Epoxycaryophyllene
(-)-b-Caryophyllene epoxide
(-)-Epoxydihydrocaryophyllene
(-)-caryophyllene oxide
b-Caryophyllene oxide
Caryophyllene 4b,5a-oxide
β-Caryophyllene oxide

石竹素生物活性

[ 描述 ]:

Caryophyllene oxide 是从 Annona squamosa L. bark. 中分离得到的,具有镇痛和抗炎活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Chavan MJ, et al. Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine. 2010 Feb;17(2):149-51.

石竹素物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
279.7±19.0 °C at 760 mmHg

[ 熔点 ]:
62-63ºC(lit.)

[ 分子式 ]:
C₁₅H₂₄O

[ 分子量 ]:
220.350

[ 闪点 ]:
119.7±19.5 °C

[ 精确质量 ]:
220.182709

[ PSA ]:
12.53000

[ LogP ]:
4.57

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.507

[ 储存条件 ]:
库房低温通风干燥

石竹素MSDS

石竹素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5530000

CHEMICAL NAME :: 5-Oxatricyclo(8.2.0.0(sup 4,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

CAS REGISTRY NUMBER :: 1139-30-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24-O

MOLECULAR WEIGHT :: 220.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,661,1983

石竹素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
RP5530000

[ 海关编码 ]:
29109000

石竹素合成路线

石竹素上下游产品

石竹素上游产品

石竹素下游产品

石竹素制备

1. 烟草：OR，26；将石竹烯在接近室温的条件下，用过酸进行氧化，便可得到环氧石竹烯。

石竹素文献

Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense.

J. Nat. Prod. 74 , 559-66, (2011)

In a survey of plants from Ecuador with antiprotozoal activity, Cupania cinerea was found to show significant in vitro activity against the Plasmodium falciparum K1 strain and Trypanosoma brucei rhode...

Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.

J. Nat. Prod. 69 , 1429-34, (2006)

Microbial transformation of the sesquiterpene (-)-caryophyllene oxide (1) [(1R,4R,5R,9S)-4,5-epoxycaryophyllan-8(13)-ene] by a number of fungi, using a standard two-stage fermentation technique, has a...

H.M.R. Hoffmann, U. Vogt

Synlett , 581, (1990)

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石竹素