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3,3,5-三甲基环已醇

3,3,5-三甲基环已醇用途

是合成环扁桃酸酯的中间体，也是合成新型增塑剂、润滑剂、二腈、二胺和醇的中间体

3,3,5-三甲基环已醇名称

[ CAS 号 ]:
116-02-9

[ 中文名 ]:
3,3,5-三甲基环已醇

[ 英文名 ]:
3,3,5-Trimethylcyclohexanol

[中文别名 ]:

[英文别名 ]:

HOMOMENTHOL
MFCD00019378
trimethylcyclohexanol
EINECS 204-122-7
TMC
Cyclohexanol, 3,3,5-trimethyl-
3,3,5-trimethyl-cyclohexanol
Isophorol,dihydro
3,3,5-Trimethylcyclohexanol
3,5,5-Trimethylcyclohexanol

3,3,5-三甲基环已醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
187.7±8.0 °C at 760 mmHg

[ 熔点 ]:
30-32ºC

[ 分子式 ]:
C₉H₁₈O

[ 分子量 ]:
142.239

[ 闪点 ]:
73.2±10.9 °C

[ 精确质量 ]:
142.135757

[ PSA ]:
20.23000

[ LogP ]:
2.87

[ 外观性状 ]:
白色结晶块

[ 蒸汽压 ]:
0.2±0.8 mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
室温，干燥，密封

[ 水溶解性 ]:
1.8 g/L (20 ºC)

3,3,5-三甲基环已醇MSDS

详细MSDS(安全技术说明书)

3,3,5-三甲基环已醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GW0875000

CHEMICAL NAME :: Cyclohexanol, 3,3,5-trimethyl-

CAS REGISTRY NUMBER :: 116-02-9

BEILSTEIN REFERENCE NO. :: 2203314

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H18-O

MOLECULAR WEIGHT :: 142.27

WISWESSER LINE NOTATION :: L6TJ A1 A1 CQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,1007,1974

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,216,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,216,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,60,1949 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1317 No. of Facilities: 88 (estimated) No. of Industries: 2 No. of Occupations: 14 No. of Employees: 4164 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1317 No. of Facilities: 44 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 355 (estimated) No. of Female Employees: 133 (estimated)

3,3,5-三甲基环已醇安全信息

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S39

[ RTECS号 ]:
GW0875000

3,3,5-三甲基环已醇合成路线

详细合成路线

3,3,5-三甲基环已醇上下游产品

3,3,5-三甲基环已醇上游产品

3,3,5-三甲基环已醇下游产品

3,3,5-三甲基环已醇制备

1.用1,5,5-三甲基环己烯-3-酮经还原制得。

于高压釜中加入异佛尔酮(2)138g（1mol），Ranney Ni 79g。先用氮气置换空气，再用氢气赶尽氮气后，搅拌下加热至130℃左右，通入氢气，至压力0.7Mpa，保温保压反应9h左右，直至不再吸氢为止。冷却，过滤，减压蒸馏，收集76～86℃/1.33kPa的馏分。再进一步分馏，收集84～86℃/1.33kPa的馏分，得3,3,5-三甲基环己醇(1)105g，收率74.5%