<生产厂家价格>

2,2-二苯基乙酸

2,2-二苯基乙酸用途

用于有机合成

2,2-二苯基乙酸名称

[ CAS 号 ]:
117-34-0

[ 中文名 ]:
2,2-二苯基乙酸

[ 英文名 ]:
2,2-Diphenylacetic acid

[中文别名 ]:

[英文别名 ]:

Benzeneacetic acid, α-phenyl-
MFCD00004251
1,1-Diphenylacetic acid
Diphenylacetic acid
α,α-Diphenylacetic acid
2,2-Diphenylacetic acid
acetic acid, diphenyl-
Diphenylmethane-α-carboxylic Acid
EINECS 204-185-0
Acetic acid,diphenyl

2,2-二苯基乙酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
285.0±7.0 °C at 760 mmHg

[ 熔点 ]:
147-149 °C(lit.)

[ 分子式 ]:
C₁₄H₁₂O₂

[ 分子量 ]:
212.244

[ 闪点 ]:
140.4±14.7 °C

[ 精确质量 ]:
212.083725

[ PSA ]:
37.30000

[ LogP ]:
3.25

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.599

[ 储存条件 ]:
室温

2,2-二苯基乙酸MSDS

2,2-二苯基乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH2515000

CHEMICAL NAME :: Acetic acid, diphenyl-

CAS REGISTRY NUMBER :: 117-34-0

BEILSTEIN REFERENCE NO. :: 1910978

LAST UPDATED :: 199803

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H12-O2

MOLECULAR WEIGHT :: 212.26

WISWESSER LINE NOTATION :: QVYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5540 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33240 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

REFERENCE :: GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 17,48,1978

2,2-二苯基乙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AH2515000

[ 海关编码 ]:
29163900

2,2-二苯基乙酸合成路线

2,2-二苯基乙酸上下游产品

2,2-二苯基乙酸上游产品

2,2-二苯基乙酸下游产品

2,2-二苯基乙酸制备

1.由二苯羟乙酸还原而得。

2.制法：

于1L反应瓶中加入冰醋酸250mL，红磷15g，碘5g，15～20min后反应完全。加入5mL水及二苯基乙醇酸(2)100g（0.44mol），回流反应至少2.5h。过滤除去未反应的红磷，趁热将滤液搅拌下倒入含20～25g碳酸氢钠的1L冷水中，过滤析出的白色或浅黄色固体，冷水洗涤，干燥，得化合物(1)88～90g,收率94%～99%，mp141～144℃，用50%的乙醇重结晶，得白色固体，mp144～155℃。

2,2-二苯基乙酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,2-二苯基乙酸文献

Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.

Eur. J. Med. Chem. 43 , 2056-66, (2008)

Several 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were prepared by condensation of 4-amino-5-substituted-3-mercapto-(4H)-1,2,4-triazoles (3a,b) with various substituted aromatic acid...

Two-cationic 2-methylbenzothiazole derivatives as green light absorbed sensitizers in initiation of free radical polymerization.

Colloid Polym. Sci. 293 , 1865-1876, (2015)

N-Methylpyridinium esters derivatives of 2-methylbenzothiazole hemicyanine dyes photoinitiators/photosensitizers derived from N-propyl-3-[N-2-methylbenzothiazolo]-4-pyridyno phenylacetic acid ester di...

Effect of renal dysfunction on the individual components of the acyl-glucuronide futile cycle.

J. Pharmacol. Exp. Ther. 251(1) , 288-94, (1989)

Drugs which are cleared predominantly by forming acyl-glucuronides undergo a futile cycle in which plasma drug clearance is a function of the formation, hydrolysis and renal clearance of the glucuroni...

更多文献