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二苯乙醇酸

二苯乙醇酸用途

【用途一】
胃复康的中间体。
【用途二】
测定锆。中间体。

二苯乙醇酸名称

[ CAS 号 ]:
76-93-7

[ 中文名 ]:
二苯基羟基乙酸

[ 英文名 ]:
Benzilic acid

[中文别名 ]:

[英文别名 ]:

2-hydroxy-2,2-diphenylacetic acid
Benzylic acid
EINECS 200-993-2
Benzeneacetic acid, α-hydroxy-α-phenyl-
Benzilic acid
2-hydroxy-2,2-diphenylethanoic acid
Diphenylhydroxyacetic acid
2,2-diphenyl-2-hydroxyethanoic acid
Diphenylglycolic acid
4-10-00-01256 (Beilstein Handbook Reference)

二苯乙醇酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
409.0±40.0 °C at 760 mmHg

[ 熔点 ]:
149-151 °C(lit.)

[ 分子式 ]:
C₁₄H₁₂O₃

[ 分子量 ]:
228.243

[ 闪点 ]:
215.3±23.8 °C

[ 精确质量 ]:
228.078644

[ PSA ]:
57.53000

[ LogP ]:
3.03

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.623

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

[ 水溶解性 ]:
1.41 g/L (25 ºC)

二苯乙醇酸MSDS

二苯乙醇酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD2064000

CHEMICAL NAME :: Benzilic acid

CAS REGISTRY NUMBER :: 76-93-7

BEILSTEIN REFERENCE NO. :: 0521402

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958

二苯乙醇酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36-S36/37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DD2064000

[ 海关编码 ]:
29181980

二苯乙醇酸合成路线

二苯乙醇酸上下游产品

二苯乙醇酸上游产品

二苯乙醇酸下游产品

二苯乙醇酸制备

由苯偶姻经氧化、转位而得。苯偶姻经硝酸氧化得到联苯酰，将其加入氢氧化钠溶液中，在100-110℃反应6h，加水稀释，然后用稀硫酸调节pH至3.5-4.0。捞出浮油，加活性炭脱色0.5h，过滤，滤液加硫酸至pH值为2，甩滤、水洗、干燥即得成品。另一种方法是使苯偶姻与溴酸钾反应：将苯偶姻、水、氢氧化钠和溴酸钾在80-90℃搅拌反应3h，再将反应混合物用2倍水稀释，加稀硫酸中和至pH值为8，滤去不溶物，滤液用盐酸酸化至pH<SPAN style="FONT-SIZE: 9pt; FONT-FAMILY: 宋体;

二苯乙醇酸海关

[ 海关编码 ]: 29181980

二苯乙醇酸文献

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Bioorg. Med. Chem. 17 , 5219-28, (2009)

In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ...

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