6581-06-2

• 常用中文名：二苯乙醇酸-3-奎宁环酯
• 常用英文名：3-Quinuclidinyl benzilate
• CAS号：6581-06-2
• 分子式：C₂₁H₂₃NO₃
• 分子量：337.41200
• 相关类别： 有机原料 杂环化合物
• 发布时间：2018-07-18 00:09:09
• 更新时间：2024-01-03 20:35:28
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名称

• 中文名: 二苯乙醇酸-3-奎宁环酯
• 英文名: 3-Quinuclidinyl benzilate
• 中文别名: 3-二苯羟乙酸奎宁脂
• 英文别名: ea2277; Ro 2-330; ro2-3308; CS 4030; 3-Benziloyloxyquinuclidine; 3-Chinuclidylbenzilate; (+/-)-3-quinuclidinyl benzilate; 1-azabicyclo[2.2.2]octan-3-yl 2-hydroxy-2,2-diphenylacetate; quinuclidinyl benzilate

物化性质

• 密度: 1.25g/cm3
• 沸点: 439ºC at 760 mmHg
• 熔点: 164ºC
• 分子式: C₂₁H₂₃NO₃
• 分子量: 337.41200
• 闪点: 219.3ºC
• 精确质量: 337.16800
• PSA: 49.77000
• LogP: 2.49780
• 外观性状: powder | white
• 折射率: 1.637
• 储存条件: 库房低温,通风,干燥,与食品原料分开存放
• 水溶解性: chloroform: but decomposes within 24 hrssoluble

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DD4638000 CHEMICAL NAME : Benzilic acid, 3-quinuclidinyl ester CAS REGISTRY NUMBER : 6581-06-2 LAST UPDATED : 199604 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C21-H23-N-O3 MOLECULAR WEIGHT : 337.45 WISWESSER LINE NOTATION : T66 A B CNTJ AOVXQR&R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 4500 ng/kg TOXIC EFFECTS : Cardiac - change in rate TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 4800 ng/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - local anesthetic Behavioral - hallucinations, distorted perceptions Behavioral - ataxia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human DOSE/DURATION : 5 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - ataxia Gastrointestinal - nausea or vomiting TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 103 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Dominant lethal test MUTATION DATA TEST SYSTEM : Rodent - hamster DOSE/DURATION : 40 mg/kg/6H (Intermittent) REFERENCE : ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300
• 警示性声明: P264-P301 + P310
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 28-36/37-45
• 危险品运输编码: UN 2811 6.1 / PGII
• WGK德国: 3
• RTECS号: DD4638000
• 海关编码: 2933391000

合成路线

1619-34-7 ~% 6581-06-2

文献：Journal of the American Chemical Society, , vol. 74, p. 2219

3731-38-2 ~% 6581-06-2

文献：Journal of the American Chemical Society, , vol. 74, p. 2219

1838-39-7 ~% 6581-06-2

文献：Journal of the American Chemical Society, , vol. 74, p. 2219

1193-65-3 ~% 6581-06-2

文献：Journal of the American Chemical Society, , vol. 74, p. 2219

76-89-1 ~% 6581-06-2

文献：US2843593 , ;

76-93-7 1619-34-7 ~% 6581-06-2

文献：Pharmaceutical Chemistry Journal, , vol. 19, # 9 p. 602 - 604 Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 9 p. 1060 - 1061

海关

海关编码	2933391000
中文概述	2933391000 二苯乙醇酸-3-奎宁环酯〔即BZ〕。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
监管条件	2.两用物项和技术进口许可证 3.两用物项和技术出口许可证
Summary	2933391000 quinuclidin-3-yl 2-hydroxy-2,2-diphenylacetate。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%