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氟曲马唑

氟曲马唑用途

氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。

氟曲马唑名称

[ CAS 号 ]:
119006-77-8

[ 中文名 ]:
氟曲马唑

[ 英文名 ]:
FLUTRIMAZOLE

[中文别名 ]:

氟曲吗唑

[英文别名 ]:

Flutrimazolum
Flutrimazole (INN)
FLUTRIMAZOLE
Micetal
Flutrimazolum [INN-Latin]
Flutrimazol [INN-Spanish]
MFCD00865591
Flutrimazol
UR-4056

氟曲马唑生物活性

[ 描述 ]:

氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

[2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

氟曲马唑物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
457.1±40.0 °C at 760 mmHg

[ 熔点 ]:
161-166ºC

[ 分子式 ]:
C₂₂H₁₆F₂N₂

[ 分子量 ]:
346.373

[ 闪点 ]:
230.3±27.3 °C

[ 精确质量 ]:
346.128143

[ PSA ]:
17.82000

[ LogP ]:
4.95

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.590

[ 储存条件 ]:
室温，干燥

氟曲马唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI6259450

CHEMICAL NAME :: 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-

CAS REGISTRY NUMBER :: 119006-77-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H16-F2-N2

MOLECULAR WEIGHT :: 346.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 808 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1079 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

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氟曲马唑文献

Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream.

Mycoses 43(9-10) , 355-65, (2000)

A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal...

Efficacy of flutrimazole 1% powder in the treatment of tinea pedis.

Mycoses 46(3-4) , 126-31, (2003)

The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comp...

Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial.

Mycoses 53(6) , 522-9, (2010)

Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its...

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