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N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)用途

N、 N-二甲基鞘氨醇是SphK(鞘氨醇激酶)的有效抑制剂,是在各种组织和肿瘤细胞系中产生的鞘氨醇的内源性代谢产物。

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)名称

[ CAS 号 ]:
119567-63-4

[ 中文名 ]:
N,N-二甲基鞘胺醇

[ 英文名 ]:
N,N-Dimethylsphingosine

[中文别名 ]:

D-赤-N,N-二甲基鞘氨醇

[英文别名 ]:

N,N-Dimethyl-D-erythrosphingenine
d-erythro-sphingosine, n,n-dimethyl-
(E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol
(2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
N,N-Dimethylsphingosine
N,N-Dimethyl-D-erythro-Sphingosine
(2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol
MFCD00153960

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)生物活性

[ 描述 ]:

N、 N-二甲基鞘氨醇是SphK(鞘氨醇激酶)的有效抑制剂,是在各种组织和肿瘤细胞系中产生的鞘氨醇的内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> SPHK

[参考文献]

[1]. Endo K, et al. Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Res.

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
447.2±45.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₄₁NO₂

[ 分子量 ]:
327.545

[ 闪点 ]:
186.1±27.4 °C

[ 精确质量 ]:
327.313721

[ PSA ]:
43.70000

[ LogP ]:
7.64

[ 外观性状 ]:
透明无色至淡的黄色液体/白色至灰白色粉末

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.483

[ 储存条件 ]:
−20°C

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)MSDS

详细MSDS(安全技术说明书)

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)安全信息

[ 危害码 (欧洲) ]:
F: Flammable;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S7-S16

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ WGK德国 ]:
1

N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)文献

Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors.

Am. J. Pathol. 185(2) , 387-98, (2015)

Sphingosine 1-phosphate (S1P) is involved in multiple pathological processes, including fibrogenesis. S1P participates in mouse liver fibrogenesis via a paracrine manner. Herein, we investigated the i...

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

Cancer Res. 51(6) , 1613-8, (1991)

Sphingosine (SPN) has been claimed to be a negative modulator of transmembrane signaling through protein kinase C (PK-C) or some yet unidentified mechanism [for review see Y. A. Hannun and R. M. Bell,...

Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.

Biochem. Pharmacol. 44(8) , 1585-95, (1992)

Neutrophils display three major functions: (i) oxidative burst, (ii) phagokinetic activity, and (iii) trans-endothelial migration. Sphingosine (SPN) is known to inhibit oxidative burst in human neutro...

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