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比阿培南

比阿培南用途

【用途一】
为全合成的沙星类抗菌药

比阿培南名称

[ CAS 号 ]:
120410-24-4

[ 中文名 ]:
比阿培南

[ 英文名 ]:
Biapenem

[中文别名 ]:

[英文别名 ]:

Biapenem (JAN/USAN)
EINECS 204-352-8
BiapeneM Crude
Biapenem [USAN:INN]
LJ C10627
omegacin
MFCD00864863
Biapenem
LJ C10,627
Biapenern

比阿培南生物活性

[ 描述 ]:

Biapenem是不经肠道的广谱碳青霉烯抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Perry, C.M. and T. Ibbotson, Biapenem. Drugs, 2002. 62(15): p. 2221-34; discussion 2235.

[2]. Kasahara, S., et al., [Clinical effects of biapenem on febrile neutropenia in patients with hematological malignancy]. Jpn J Antibiot, 2008. 61(3): p. 115-21.

[相关活性小分子]

比阿培南物理化学性质

[ 熔点 ]:
265-271°C (dec.)

[ 分子式 ]:
C₁₅H₁₈N₄O₄S

[ 分子量 ]:
350.393

[ 精确质量 ]:
350.104889

[ PSA ]:
127.67000

[ 外观性状 ]:
白色至淡黄色粉末

[ 折射率 ]:
1.651

[ 储存条件 ]:
-20?C Freezer

比阿培南安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

比阿培南合成路线

详细合成路线

比阿培南上下游产品

比阿培南上游产品

比阿培南下游产品

比阿培南文献

Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens' antibacterial susceptibility.

J. Infect. Chemother. 21 , 410-20, (2015)

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society of Chemotherapy, Japanese Association for Infec...

Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii.

Antimicrob. Agents Chemother. 59 , 2286-98, (2015)

Acinetobacter baumannii is among the most dangerous pathogens and emergence of resistance is highly problematic. Our objective was to identify and rationally optimize β-lactam-plus-aminoglycoside comb...

Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions.

PLoS ONE 7(1) , e30079, (2012)

The first line of defense by bacteria against β-lactam antibiotics is the expression of β-lactamases, which cleave the amide bond of the β-lactam ring. In the reaction of biapenem inactivation by B2 m...

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