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4-氯-3-硝基三氟甲苯

4-氯-3-硝基三氟甲苯用途

用作医药中间体

4-氯-3-硝基三氟甲苯名称

[ CAS 号 ]:
121-17-5

[ 中文名 ]:
4-氯-3-硝基三氟甲苯

[ 英文名 ]:
3-Nitro-4-chlorobenzotrifluoride

[中文别名 ]:

[英文别名 ]:

4-chloro-3-nitro-benzotrifluorid
4-chloro-α,α,α-trifluoro-3-nitrotoluene
Benzene, 1-chloro-2-nitro-4-(trifluoromethyl)-
4-CHLORO-3-NITROTRIFLUOROBENZENE
MFCD00007084
4-chloro-3-nitro-trifluoroMethyl
3-Nitro-4-chlorobenzotrifluoride
Toluene, 4-chloro-α,α,α-trifluoro-3-nitro-
2-chloro-5-trifluoromethyl-nitrobenzene
CMNT

4-氯-3-硝基三氟甲苯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
225.3±35.0 °C at 760 mmHg

[ 熔点 ]:
-2 °C

[ 分子式 ]:
C₇H₃ClF₃NO₂

[ 分子量 ]:
225.552

[ 闪点 ]:
101.7±0.0 °C

[ 精确质量 ]:
224.980438

[ PSA ]:
45.82000

[ LogP ]:
3.08

[ 外观性状 ]:
透明黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.493

[ 储存条件 ]:
库房通风低温干燥,与食品分开储运

[ 水溶解性 ]:
Insoluble

4-氯-3-硝基三氟甲苯MSDS

4-氯-3-硝基三氟甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9140000

CHEMICAL NAME :: Toluene, 4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-

CAS REGISTRY NUMBER :: 121-17-5

BEILSTEIN REFERENCE NO. :: 0523986

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C7-H3-Cl-F3-N-O2

MOLECULAR WEIGHT :: 225.56

WISWESSER LINE NOTATION :: WNR BG EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1075 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg/4W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Embryo

DOSE/DURATION :: 1 gm/L

REFERENCE :: AISSAW Annali dell'Istituto Superiore di Sanita. (Istituto Poligrafico e Zecca dello Stato, Piazza Verdi, 10 Rome, Italy) V.1- 1965- Volume(issue)/page/year: 18,123,1982

4-氯-3-硝基三氟甲苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
UN 2307 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
XS9140000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29049085

4-氯-3-硝基三氟甲苯合成路线

4-氯-3-硝基三氟甲苯上下游产品

4-氯-3-硝基三氟甲苯上游产品

4-氯-3-硝基三氟甲苯下游产品

4-氯-3-硝基三氟甲苯制备

由邻氯三氟甲基苯硝化而得。

4-氯-3-硝基三氟甲苯海关

[ 海关编码 ]: 2904909090

[ 中文概述 ]:
2904909090 其他烃的磺化、硝化、亚硝化衍生物（不论是否卤化）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-氯-3-硝基三氟甲苯文献

A case of multiple sensitization to three halogeno-substituted mono-nitrobenzenes.

Ital. Gen. Rev. Dermatol. 15(2) , 107-12, (1978)

A case of occupational contact dermatitis in a female chemical pharmaceutical laboratory researcher is described. The allergological investigation revealed a state of sensitization to three mono-nitro...

In vitro mutational studies with trifluralin and trifluorotoluene derivatives.

Ann. Ist. Super. Sanita 18(1) , 123-6, (1982)

[Subchronic oral toxicity in the rat of 3-nitro-4-chloro-alpha,alpha,alpha-trifluorotoluene (NCTT)].

Ann. Ist. Super. Sanita 19(2-3) , 385-9, (1983)

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