4-氯三氟甲苯

4-氯三氟甲苯用途

【用途一】
用作农药、医药、染料等中间体
【用途二】
对氯三氟甲苯是除草剂氟乐灵、乙氧氟草醚、三氟羧草醚、氟磺胺草醚、乙羧氟草醚、乳氟禾草灵等的中间体。
【用途三】
本品用作氟乐灵、乙丁氟乐灵、氟酯肟草醚、氟碘胺草醚，以及羧氟醚除草剂等；还可用于合成医药，另外，还可用于染料工业。

4-氯三氟甲苯名称

[ CAS 号 ]:
98-56-6

[ 中文名 ]:
对氯三氟甲苯

[ 英文名 ]:
4-Chlorobenzotrifluoride

[中文别名 ]:

[英文别名 ]:

Benzene, 1-chloro-4-(trifluoromethyl)-
Toluene, p-chloro-α,α,α-trifluoro-
MFCD00000627
4-Chloro-α,α,α-trifluorotoluene
EINECS 202-681-1
PCBTF
GR DXFFF
4-Chlorobenzotrifluo
P-CHLOROBENOTRIFLUORIDE
p-Chloro-α,α,α-trifluorotoluene

4-氯三氟甲苯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
138.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-36 °C

[ 分子式 ]:
C₇H₄ClF₃

[ 分子量 ]:
180.555

[ 闪点 ]:
47.2±0.0 °C

[ 精确质量 ]:
179.995361

[ LogP ]:
3.46

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
8.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品原料分开储运

[ 稳定性 ]:
Stable, but heat and light sensitive. Reacts vigorously with oxidizing agents. Flammable. Incompatible with sodium dimethyl sulfonate, strong bases.

[ 水溶解性 ]:
29 ppm (23 ºC)

4-氯三氟甲苯MSDS

4-氯三氟甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9145000

CHEMICAL NAME :: Toluene, p-chloro-alpha,alpha,alpha-trifluoro-

CAS REGISTRY NUMBER :: 98-56-6

BEILSTEIN REFERENCE NO. :: 0510203

LAST UPDATED :: 199712

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C7-H4-Cl-F3

MOLECULAR WEIGHT :: 180.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 gm/kg/28D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/m3/24H/17W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/6H/4W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in calcium Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg/14D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Embryo

DOSE/DURATION :: 1 gm/L

REFERENCE :: AISSAW Annali dell'Istituto Superiore di Sanita. (Istituto Poligrafico e Zecca dello Stato, Piazza Verdi, 10 Rome, Italy) V.1- 1965- Volume(issue)/page/year: 18,123,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 20 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84021 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated)

4-氯三氟甲苯安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H317-H411

[ 警示性声明 ]:
P210-P273-P280-P333 + P313-P391-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R10;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25-S16

[ 危险品运输编码 ]:
UN 2234 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
XS9145000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29036990

4-氯三氟甲苯合成路线

4-氯三氟甲苯上下游产品

4-氯三氟甲苯上游产品

4-氯三氟甲苯下游产品

4-氯三氟甲苯制备

1、由对氯甲苯经侧链光氯化、液相氟化而得：氯化：将对氯甲苯投入光氯化反应器中，加热至120-150℃，在日光灯照射下通氯反应。每隔10-15min取微量反应液进行气相色谱分析。当对氯三氯甲苯含量大于90%后停止反应。产物减压蒸馏得对氯三氯甲苯。收率为90-95%。氟化：将对氯三氯甲苯投入氟化反应釜，按摩尔比加入4-5倍的无水氟化氢。升温后在1.9-2.4MPa下反应，直至反应压力不再上升时为止。反应过程放出的氯化氢气体用碱吸收，反应物经中和、水蒸气蒸馏得粗品。再经常压蒸馏得沸程为138-140℃的对氯三氟甲苯液体。收率为80-90%。

2、其制备方法是将对氯三氯甲苯加入氟化反应器，并将冷凝器通冷冻盐水冷却，将计量的液体氟化氢用干燥空气从钢瓶压到氟化反应器，然后加催化剂，关调节阀，搅拌，升温反应，反应产生的氟化氢伴随挥发的氟化氢和有机物冷凝回流，冷凝回收的液体氟化氢存于回收槽，反应结束后，氟化产物对氯三氟甲苯进入蒸馏釜，在真空系统下升温精馏得产品。

4-氯三氟甲苯海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-氯三氟甲苯文献

Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.

Eur. J. Med. Chem. 43 , 478-85, (2008)

Values of in vitro gas to lung partition coefficients, K(lung), of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K(lung) yielded a cor...

In vitro mutational studies with trifluralin and trifluorotoluene derivatives.

Ann. Ist. Super. Sanita 18(1) , 123-6, (1982)

Application of molecular encapsulation for toxicology studies: comparative toxicity of p-Chloro-alpha, alpha, alpha-trifluorotoluene in alpha-cyclodextrin vehicle versus corn oil vehicle in male and female Fischer 344 rats and B6C3F1 mice.

Fundam. Appl. Toxicol. 18 , 460-70, (1992)

The application of alpha-cyclodextrin (alpha-CD) as an alternative vehicle for water insoluble and volatile chemicals was investigated in toxicity studies of p-chloro-alpha, alpha, alpha-trifluorotolu...

更多文献