三氟甲苯

三氟甲苯用途

【用途一】
用途：用于制造药物、染料，并用作硫化剂、杀虫剂等
【用途二】
三氟甲基苯是氟化学中重要中间体，可以制备氟草隆、氟咯草酮、吡氟草胺等除草剂，也是医药的重要中间体。
【用途三】
医药、染料的中间体，溶剂。并用作硫化剂及绝缘油的制造。
【用途四】
医药；染料的中间体，溶剂。并用作硫化剂及绝缘油的制造。

三氟甲苯名称

[ CAS 号 ]:
98-08-8

[ 中文名 ]:
三氟甲苯

[ 英文名 ]:
Benzotrifluoride

[中文别名 ]:

[英文别名 ]:

Triflorotoluene
(Trifluoromethyl)benzene
benzenylfluoride
Trifluoromethylbenzene
Benzotrifluoide
Trifluoromethyl-benzene
Benzotrifluoride
3-trifluoromethyl-benzene
EINECS 202-635-0
Oxsol2000

三氟甲苯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
104.8±35.0 °C at 760 mmHg

[ 熔点 ]:
−29 °C(lit.)

[ 分子式 ]:
C₇H₅F₃

[ 分子量 ]:
146.110

[ 闪点 ]:
12.2±0.0 °C

[ 精确质量 ]:
146.034332

[ LogP ]:
2.79

[ 外观性状 ]:
透明液体带有芳香气味

[ 蒸汽压 ]:
35.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.422

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 21 ºC

三氟甲苯MSDS

三氟甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT9450000

CHEMICAL NAME :: Toluene, alpha,alpha,alpha-trifluoro-

CAS REGISTRY NUMBER :: 98-08-8

BEILSTEIN REFERENCE NO. :: 1906908

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H5-F3

MOLECULAR WEIGHT :: 146.12

WISWESSER LINE NOTATION :: FXFFR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70810 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,25,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10000 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,131,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 92240 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,25,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 130,250,1928

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 92 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(3),6,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15500 mg/kg/7W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(2),86,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 100 mg/m3 JAN 1993

三氟甲苯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H315-H319-H340-H350-H372

[ 警示性声明 ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R51/53

[ 安全声明 (欧洲) ]:
S53-S26-S36/37-S45-S62-S61-S23-S16

[ 危险品运输编码 ]:
UN 2338 3/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
XT9450000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2903999090

三氟甲苯合成路线

三氟甲苯上下游产品

三氟甲苯上游产品

三氟甲苯下游产品

三氟甲苯制备

1、由ω,ω,ω-三氯甲苯与无水氟化氢作用而得。ω,ω,ω-三氯甲苯与无水氟化氢的摩尔配比为1：3.88，反应在温度为80-104℃，压力为1.67-1.77MPa下进行2-3h。收率为72.1%。由于无水氟化氢便宜易得，设备易解决，不需特殊钢材，成本低，适合工业化。

2、由ω,ω,ω-三氟甲苯与三氟化锑作用而得。将ωωω三氟甲苯和三氟化锑放在反应锅内加热蒸馏，馏出液即三氟甲基苯粗品。用5%盐酸洗涤，再加5%氢氧化钠溶液，加热蒸馏，收集80-105℃馏分。分去上层液，下层液用无水氯化钙干燥，过滤后得三氟甲基苯。收率75%。此法耗用锑化物，成本较高，一般只在实验室条件下采用比较方便。

3、其制备方法是以甲苯为原料，先用氯气在催化剂存在下侧链氯化，得α，α，α-三氯甲苯，然后与氟化氢反应得产品。

三氟甲苯海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

三氟甲苯文献

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