代森锌

代森锌用途

【用途一】
叶面用保护性杀菌剂，主要用于防治麦类、蔬菜、葡萄、果树和烟草等作物的多种真菌病害
【用途二】
属叶面保护性杀菌剂，主要用于防治麦类、蔬菜、葡萄、果树和烟草等作物的多种真菌病害
【用途三】
广谱性、保护性杀菌剂。可用于防治水稻、麦类、蔬菜、葡萄、果树、烟草等作物的多种病害，如麦类锈病、玉米大斑病、茶赤星病、烟草立枯病、炭疽病、野大病、花生褐斑病、马铃薯疫病、疮痂病、黑痣病以及苹果、梨、桃、柑橘、葡萄、蔬菜等多种病害。一般用80%可湿性粉剂500～800倍液喷雾。
【用途四】
该品为叶面保护性杀菌剂。主要用于防治麦类、蔬菜、葡萄、果树和烟草等作物的多种直菌病害。

代森锌名称

[ CAS 号 ]:
12122-67-7

[ 中文名 ]:
代森锌

[ 英文名 ]:
Zineb

[中文别名 ]:

[英文别名 ]:

cineb
Tritoftorol
Zinc ethane-1,2-diyldicarbamodithioate
MFCD00067266
kypzin
dipher
zidan
EINECS 235-180-1
aspor
Zinc-ethylenebis(dithiocarbamate)

代森锌生物活性

[ 描述 ]:

Zineb是一种二硫代氨基甲酸酯类农业杀菌剂。它的毒性相对较低,几乎没有证据表明接触会对人体造成伤害。氧化应激是导致由锌网引起的疾病的主要因素之一。Zineb不会改变任何超氧化物歧化酶的活性。过氧化氢酶(CAT)活性仅被Zineb降低。

[ 相关类别 ]:

研究领域 >> 其他

代森锌物理化学性质

[ 沸点 ]:
308.2ºC at 760mmHg

[ 熔点 ]:
157ºC (decomposes)

[ 分子式 ]:
C₄H₆N₂S₄Zn

[ 分子量 ]:
275.773

[ 闪点 ]:
140.2ºC

[ 精确质量 ]:
273.870514

[ PSA ]:
88.24000

[ LogP ]:
0.60850

[ 外观性状 ]:
一种灰白色粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

代森锌MSDS

详细MSDS(安全技术说明书)

代森锌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZH3325000

CHEMICAL NAME :: Zinc, (ethylenebis(dithiocarbamato))-

CAS REGISTRY NUMBER :: 12122-67-7

LAST UPDATED :: 199803

DATA ITEMS CITED :: 54

MOLECULAR FORMULA :: C4-H6-N2-S4.Zn

MOLECULAR WEIGHT :: 275.73

WISWESSER LINE NOTATION :: T9MYS-ZN-SYMTJ BUS FUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1940 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/2W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 gm/kg/30D-I

TOXIC EFFECTS :: Endocrine - other changes Endocrine - changes in pituitary weight Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 364 gm/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Endocrine - thyroid weight (goiter) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg/5D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18200 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Liver - liver function tests impaired Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 10800 mg/kg/39W-I

TOXIC EFFECTS :: Endocrine - evidence of thyroid hypofunction Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 53580 mg/kg/94W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 mg/kg/5W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1760 mg/kg female 11-21 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 gm/kg/2.5Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8 gm/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8 mg/kg

SEX/DURATION :: female 16 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 20 mg/m3/4H

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 28 gm/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(1),80,1980 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,245,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,245,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 14,49,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83787 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 72 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83787 No. of Facilities: 291 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3205 (estimated)

代森锌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H335

[ 警示性声明 ]:
P261-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R37;R43

[ 安全声明 (欧洲) ]:
S8-S24/25-S46

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
ZH3325000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909055

代森锌合成路线

详细合成路线

代森锌上下游产品

代森锌上游产品

代森锌下游产品

代森锌制备

【方法一】
先合成代森钠。可以采用一步法或两步法。两步法有利于控制副产物三硫代碳酸钠的生成，质量好，收率也高。反应温度控制在<35℃，二硫化碳的滴加速度由反应温度而定。分批加入氢氧化钠溶液，加碱温度控制在35℃左右，每批都控制pH≤9。

将5%硫酸溶液缓慢地滴加到上述代森钠水溶液中，中和过量的氢氧化钠和分解副产物三硫代碳酸钠，至pH值6～7，并排除硫代氢气体。将已中和的代森钠水溶液升温加热至40～45℃，在搅拌下加入硫酸锌水溶液，搅拌30min，离心分离，清水洗涤，于93kPa下于50～60℃烘干，得代森锌。
【方法二】
由代森铵与氧化锌进行复分解而得。

代森锌海关

[ 海关编码 ]: 2930909055

[ 中文概述 ]:
2930909055 代森锌、代森锰、代森锰锌等〔包括福美胂、福美甲胂、代森铵、代森联〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2930909055 zinc(ii) ethane-1,2-diyldicarbamodithioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

代森锌文献

Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells.

Environ. Toxicol. Pharmacol. 34(2) , 556-73, (2012)

The effects of the fungicides Maneb, Mancozeb, and Zineb were investigated in transformed colon cells, HT-29, Caco2 and non-transformed cells, CCD-18Co. Significant decreases in viability were observe...

Avoidance behaviour of Eisenia fetida to carbofuran, chlorpyrifos, mancozeb and metamidophos in natural soils from the highlands of Colombia.

Chemosphere 84(5) , 651-6, (2011)

Earthworm avoidance behaviour test is an important screening tool in soil eco-toxicology. This test has been developed and validated under North American and European conditions. However, little resea...

The effects of pesticide mixtures on degradation of pendimethalin in soils.

Environ. Monit. Assess. 184(5) , 3077-84, (2012)

Most agronomic situations involve a sequence of herbicide, fungicide, and insecticide application. On the other hand, use of pesticidal combinations has become a standard practice in the production of...

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代森锌