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月桂烯

月桂烯用途

月桂烯(β-月桂烯)是一种芳香挥发性化合物,可抑制TNFα诱导的NF-κB活性。月桂烯具有抗侵袭作用[1][2]。

月桂烯名称

[ CAS 号 ]:
123-35-3

[ 中文名 ]:
月桂烯

[ 英文名 ]:
Myrcene

[中文别名 ]:

[英文别名 ]:

β-Myrcene
2-Methyl-6-methylene-2,7-octadiene
1,6-Octadiene,7-methyl-3-methylene
1,6-Octadiene, 7-methyl-3-methylene-
MFCD00008908
7-methyl-3-methylideneocta-1,6-diene
Myrcene
7-methyl--3-methylen-1,6-octadiene
b-Geraniolene
7-methyl-3-methyleneocta-1,6-diene

月桂烯生物活性

[ 描述 ]:

月桂烯(β-月桂烯)是一种芳香挥发性化合物,可抑制TNFα诱导的NF-κB活性。月桂烯具有抗侵袭作用[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

NF-κB

[参考文献]

[1]. Eunson Hwang, et al. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production. Am J Chin Med. 2017;45(5):1113-1124.

[2]. Jeong-Ho Lee, et al. Anti-invasive effect of β-myrcene, a component of the essential oil from Pinus koraiensis cones, in metastatic MDA-MB-231 human breast cancer cells. Journal of the Korean Society for Applied Biological Chemistry volume 58, pages563–569.

月桂烯物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
167.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₆

[ 分子量 ]:
136.234

[ 闪点 ]:
39.4±0.0 °C

[ 精确质量 ]:
136.125198

[ LogP ]:
4.58

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
2.3±0.1 mmHg at 25°C

[ 折射率 ]:
1.450

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Unstable - may be inhibited by the addition of ca. 400 ppm tenox GT-1 or 1000 ppm BHT. Flammable. Incompatible with strong oxidizing agents, radical initiators.

[ 水溶解性 ]:
practically insoluble

月桂烯MSDS

月桂烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG5365000

CHEMICAL NAME :: 1,6-Octadiene, 7-methyl-3-methylene-

CAS REGISTRY NUMBER :: 123-35-3

BEILSTEIN REFERENCE NO. :: 1719990

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: 1Y1&U3YU1&1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,615,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,615,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,615,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 31,31,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14 mg/kg

SEX/DURATION :: female 15-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 31,623,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1662 No. of Facilities: 200 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 801 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1662 No. of Facilities: 2650 (estimated) No. of Industries: 14 No. of Occupations: 29 No. of Employees: 25154 (estimated) No. of Female Employees: 12898 (estimated)

月桂烯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H304-H315-H319

[ 警示性声明 ]:
P210-P301 + P310-P305 + P351 + P338-P331-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R10;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S36-S37/39

[ 危险品运输编码 ]:
UN 2319 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
RG5365000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

[ 海关编码 ]:
2901299090

月桂烯合成路线

月桂烯上下游产品

月桂烯上游产品

月桂烯下游产品

月桂烯制备

1. 黄栌叶或柔布叶蒸馏液再进行精馏分离而得。

2. 烟草：FC，18；FC，40。

3. 合成：将β-蒎烯在金属管内于高温下热解而得，或用异戊二烯未原料在催化剂存在下经二聚反应制得。

月桂烯海关

[ 海关编码 ]: 2901299090

[ 中文概述 ]:
2901299090 其他不饱和无环烃。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 用作气体燃料的应报明包装容器容积, 散装货物应报明

[ Summary ]:
2901299090 unsaturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

月桂烯文献

Identification of odorants in frankincense (Boswellia sacra Flueck.) by aroma extract dilution analysis and two-dimensional gas chromatography-mass spectrometry/olfactometry.

Phytochemistry 109 , 66-75, (2014)

Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surp...

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

J. Insect Physiol. 78 , 33-46, (2015)

Phytophagous insects detect volatile compounds produced by host and non-host plants, using species-specific sets of olfactory receptor neurons (ORNs). To investigate the relationship between the range...

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob. Agents Chemother. 53 , 1898-906, (2009)

Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho...

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月桂烯