十二胺

十二胺用途

【用途一】
在地质分析中用作活性剂，也用于色谱分析
【用途二】
用于制取表面活性剂、矿物浮选剂、十二烷基季铵盐、杀菌剂、农药、乳化剂、洗涤剂等
【用途三】
有机合成中间体，用于纺织及橡胶等助剂生产。也可用以制取矿石浮选剂、十二烷基季胺盐、杀菌剂、杀虫剂、乳化剂、洗涤剂和防治皮肤灼伤养津抗菌的消毒特效剂等。
【用途四】
有机合成。用作色谱固定液.

十二胺名称

[ CAS 号 ]:
124-22-1

[ 中文名 ]:
十二烷基伯胺

[ 英文名 ]:
Dodecanamine

[中文别名 ]:

[英文别名 ]:

Dibenzo[b,e][1,4]dioxin-1-amine
Laurylamine
1-dodecanamine
1-lauryl amine
dodecyl amine
1-dodecylamine
1-Aminodibenzo-p-dioxin
1-Aminododecane,Laurylamine
EINECS 204-690-6
MFCD00008154

十二胺物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
247-249 ºC

[ 熔点 ]:
28-32 ºC

[ 分子式 ]:
C₁₂H₂₇N

[ 分子量 ]:
185.350

[ 闪点 ]:
100.4±13.1 °C

[ 精确质量 ]:
185.214355

[ PSA ]:
26.02000

[ LogP ]:
5.18

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.444

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with acid chlorides, acids, acid anhydrides, oxidizing agents.

[ 水溶解性 ]:
78 mg/L (25 ºC)

十二胺MSDS

十二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR6475000

CHEMICAL NAME :: Dodecylamine

CAS REGISTRY NUMBER :: 124-22-1

BEILSTEIN REFERENCE NO. :: 1633576

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H27-N

MOLECULAR WEIGHT :: 185.40

WISWESSER LINE NOTATION :: Z12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,438,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,438,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 219,119,1953 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 219,119,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 219,119,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1342 No. of Facilities: 47 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 377 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1342 No. of Facilities: 21 (estimated) No. of Industries: 2 No. of Occupations: 15 No. of Employees: 2134 (estimated) No. of Female Employees: 306 (estimated)

十二胺安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H304-H314-H335-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P310

[ 靶器官 ]:
Gastrointestinal tract, Immune system, Liver

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R20/21/22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S60-S61

[ 危险品运输编码 ]:
UN 3259 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
JR6475000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2921199090

十二胺合成路线

十二胺上下游产品

十二胺上游产品

十二胺下游产品

十二胺制备

生产方法简述：以月桂酸为原料在催化剂硅胶存在下通入氨气反应，生成物经水洗、干燥、减压精馏得月桂腈。将月桂腈在活性镍催化下加氢，即还原得十二胺。把月桂腈加入高压釜中，再加适量活性镍，通氮置换室内空气。在搅拌下加热至80℃，反复充氢直至不再吸收为止，保温反应3h。冷却，将所得粗品进行减压蒸馏，即得十二胺。

十二胺海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

十二胺文献

Effects of wet heat treatment on the germination of individual spores of Clostridium perfringens.

J. Appl. Microbiol. 113(4) , 824-36, (2012)

To analyse the effect of wet heat treatment on nutrient and non-nutrient germination of individual spores of Clostridium perfringens.Raman spectroscopy and differential interference contrast (DIC) mic...

Effects of the SpoVT regulatory protein on the germination and germination protein levels of spores of Bacillus subtilis.

J. Bacteriol. 194(13) , 3417-25, (2012)

Bacillus subtilis isolates lacking the SpoVT protein, which regulates gene expression in developing forespores, gave spores that released their dipicolinic acid (DPA) via germinant receptor (GR)-depen...

Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.

Small 10(24) , 5137-50, (2014)

The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of tran...

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十二胺