syringomycin E

syringomycin E用途

雪兰莪霉素E是一种抗真菌的环状脂肪去甲肽。雪兰莪霉素E通过与质膜的相互作用表现出对酿酒酵母的生长抑制。丁香霉素E导致K+流出、Ca2+内流和膜电位变化,并与通道形成相关[1][2]。

syringomycin E名称

[ CAS 号 ]:
124888-22-8

[ 英文名 ]:
syringomycin E

[英文别名 ]:

SYRINGOMYCIN E FROM PSEUDOMONAS SYRINGAE B-301D
syringomycin-E

syringomycin E生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[体外研究]

雪林霉素E(0.5μg/mL,1μg/mL；48小时)对酿酒酵母菌株第33章和第56页有抑制作用[1]。雪林霉素E是一种离子通道型,对电势跨膜分布的变化敏感[2]。

[参考文献]

[1]. Stock SD, et al. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother. 2000 May;44(5):1174-80.

[2]. Efimova SS, et al. Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host. Front Cell Dev Biol. 2020 Jun 30;8:537.

syringomycin E物理化学性质

[ 密度 ]:
1.47g/cm3

[ 分子式 ]:
C₅₃H₈₅ClN₁₄O₁₇

[ 分子量 ]:
1225.78000

[ 精确质量 ]:
1224.59000

[ PSA ]:
522.86000

[ LogP ]:
0.18720

[ 折射率 ]:
1.641

syringomycin E安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危险品运输编码 ]:
NONH for all modes of transport

syringomycin E文献

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae.

FEMS Microbiol. Lett. 358(1) , 64-71, (2014)

Syringomycin E is a cyclic lipodepsipeptide produced by strains of the plant bacterium Pseudomonas syringae pv. syringae. Genetic studies involving the yeast Saccharomyces cerevisiae have revealed tha...

Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Langmuir 23(13) , 6889-92, (2007)

We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) ...

[Transport of large organic ions through syringomycin channels in the membranes containing dipole modifiers].

Tsitologiia 53(5) , 450-6, (2011)

The effect of the membrane dipole potential (Phid) on a conductance and a steady-state number of functioning channels formed by cyclic lipodepsipeptide syringomycin E (SRE) in bilayer lipid membranes ...

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