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泼尼松龙21-磷酸二钠

泼尼松龙21-磷酸二钠用途

Prednisolone磷酸二钠是合成的糖皮质素,有抗炎和免疫调节活性。

泼尼松龙21-磷酸二钠名称

[ CAS 号 ]:
125-02-0

[ 中文名 ]:
泼尼松龙磷酸钠

[ 英文名 ]:
Prednisolone Sodium Phosphate

[中文别名 ]:

[英文别名 ]:

(11beta)
Phortisolone
Inflamase
prednisolon disodium phosphate
Prednisolone sodium phosphate
Optival
Predsol
Codelsol
Prednisolone (disodium phosphate)
prednisolone 21-disodium phosphate

泼尼松龙21-磷酸二钠生物活性

[ 描述 ]:

Prednisolone磷酸二钠是合成的糖皮质素,有抗炎和免疫调节活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95.

[2]. http://en.wikipedia.org/wiki/Prednisolone

[相关活性小分子]

泼尼松龙21-磷酸二钠物理化学性质

[ 沸点 ]:
100 °C

[ 分子式 ]:
C₂₁H₂₇Na₂O₈P

[ 分子量 ]:
484.388

[ 闪点 ]:
361.9ºC

[ 精确质量 ]:
484.123901

[ PSA ]:
156.83000

[ LogP ]:
2.55100

[ 蒸汽压 ]:
4.17E-21mmHg at 25°C

[ 储存条件 ]:
室温

泼尼松龙21-磷酸二钠MSDS

详细MSDS(安全技术说明书)

泼尼松龙21-磷酸二钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4153300

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt

CAS REGISTRY NUMBER :: 125-02-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H27-O8-P.2Na

MOLECULAR WEIGHT :: 484.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,1439,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5598 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

泼尼松龙21-磷酸二钠安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2937229000

泼尼松龙21-磷酸二钠海关

[ 海关编码 ]: 2937229000