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醋酸泼尼松

醋酸泼尼松用途

Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式,Prednisone acetate 是一种具有抗炎和免疫调节特性的糖皮质激素受体激动剂。

醋酸泼尼松名称

[ CAS 号 ]:
125-10-0

[ 中文名 ]:
醋酸泼尼松

[ 英文名 ]:
d-Corlin

[中文别名 ]:

醋酸去氢皮质素

[英文别名 ]:

d-Corlin
δ-Cortelan
Prednisone 21-acetate
EINECS 204-726-0
δ-Corlin
d-Cortelan
MFCD00200229

醋酸泼尼松生物活性

[ 描述 ]:

Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式,Prednisone acetate 是一种具有抗炎和免疫调节特性的糖皮质激素受体激动剂。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

[ 靶点 ]

glucocorticoid receptor[1]

[参考文献]

[1]. Prednisolone acetate

醋酸泼尼松物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
582.0±50.0 °C at 760 mmHg

[ 熔点 ]:
240-242°C (dec.)

[ 分子式 ]:
C₂₃H₂₈O₆

[ 分子量 ]:
400.46

[ 闪点 ]:
200.2±23.6 °C

[ 精确质量 ]:
400.188599

[ PSA ]:
97.74000

[ LogP ]:
2.66

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.580

[ 储存条件 ]:
Refrigerator

醋酸泼尼松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4154085

CHEMICAL NAME :: Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate

CAS REGISTRY NUMBER :: 125-10-0

BEILSTEIN REFERENCE NO. :: 2342061

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H28-O6

MOLECULAR WEIGHT :: 400.51

WISWESSER LINE NOTATION :: L E5 B666 CV OV AHTTT&J A1 E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 330 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 135 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3270 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1045 (estimated) No. of Female Employees: 1045 (estimated)

醋酸泼尼松安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 海关编码 ]:
2937210000

醋酸泼尼松合成路线

详细合成路线

醋酸泼尼松上下游产品

醋酸泼尼松上游产品

醋酸泼尼松下游产品

醋酸泼尼松制备

【方法一】
醋酸可的松经二氧化硒脱氢而得。

醋酸泼尼松海关

[ 海关编码 ]: 2937210000