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氮杂二苯并环辛炔胺

氮杂二苯并环辛炔胺用途

DBCO-amine 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

氮杂二苯并环辛炔胺名称

[ CAS 号 ]:
1255942-06-3

[ 中文名 ]:
氮杂二苯并环辛炔胺

[ 英文名 ]:
DBCO-Amine

[中文别名 ]:

氨基丙酰氮杂二苯并环辛炔

[英文别名 ]:

Dibenzocyclooctyne-amine
DBCO-NH2
DBCO-amine
ADIBO-AMINE

氮杂二苯并环辛炔胺生物活性

[ 描述 ]:

DBCO-amine 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接物连接ADC细胞毒素。

[参考文献]

[1]. Ermira Pazolli, et al. Splicing modulator antibody-drug conjugates and methods of use. WO2019232449A1.

氮杂二苯并环辛炔胺物理化学性质

[ 分子式 ]:
C₁₈H₁₆N₂O

[ 分子量 ]:
276.33200

[ 精确质量 ]:
276.12600

[ PSA ]:
46.33000

[ LogP ]:
3.04710

[ 储存条件 ]:
-20°C

氮杂二苯并环辛炔胺安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

氮杂二苯并环辛炔胺文献

Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.

J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010)

Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react...

Copper-free click chemistry for dynamic in vivo imaging.

Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007)

Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids...

Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

Angew. Chem. Int. Ed. Engl. 47 , 2253-2255, (2008)

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