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丙酮肟

丙酮肟用途

【用途一】
是医药、农药、染料及有机硅偶联剂的原料，也可以用于分析试剂鉴定镍、钴等
【用途二】
该品用于有机合成。作为分析试剂。用于测定钴。
【用途三】
检验钴的试剂,有机合成,新型锅炉水除氧剂，医药、农药中间体等。

丙酮肟名称

[ CAS 号 ]:
127-06-0

[ 中文名 ]:
丙酮肟

[ 英文名 ]:
Propan-2-one oxime

[中文别名 ]:

[英文别名 ]:

N-Hydroxypropan-2-imine
Acetone, oxime
β-Isonitrosopropane
MFCD00002118
Acetone oxime
2-Propanone, oxime
Acetoxime
EINECS 204-820-1
b-Isonitrosopropane
N-Hydroxy-2-propanimine

丙酮肟物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
135.0±0.0 °C at 760 mmHg

[ 熔点 ]:
60-63 °C(lit.)

[ 分子式 ]:
C₃H₇NO

[ 分子量 ]:
73.094

[ 闪点 ]:
45.2±8.0 °C

[ 精确质量 ]:
73.052765

[ PSA ]:
32.59000

[ LogP ]:
0.12

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
4.7±0.5 mmHg at 25°C

[ 折射率 ]:
1.410

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
330 g/L (20 ºC)

丙酮肟MSDS

丙酮肟毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AL6825000

CHEMICAL NAME :: Acetone, oxime

CAS REGISTRY NUMBER :: 127-06-0

BEILSTEIN REFERENCE NO. :: 1560146

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C3-H7-N-O

MOLECULAR WEIGHT :: 73.11

WISWESSER LINE NOTATION :: QNUY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - coma

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,522,1957

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 12,227,1978

丙酮肟安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN1325

[ WGK德国 ]:
3

[ RTECS号 ]:
AL6825000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2928000090

丙酮肟合成路线

丙酮肟上下游产品

丙酮肟上游产品

丙酮肟下游产品

丙酮肟制备

1.丙酮与盐酸羟胺法由丙酮与盐酸羟胺反应得到。将盐酸羟胺溶液慢慢滴加于丙酮中，反应温度控制在40-50℃。将肟化好的反应液用40%氢氧化钠中和至碱性为止(pH7-8)，冷却过滤，将滤出的粗品加入沸石，常压蒸馏，冷却得结晶成品。

2.亚硝酸钠法向用冰盐浴冷却的8L广口瓶中，加入630g（8.7mol）工业亚硝酸钠和5kg碎冰，将混合物充分搅拌；慢慢加入冷至0~5℃的亚硫酸氢钠溶液【此溶液是将490g（4.7mol）无水碳酸钠溶解在1500ml水中，通二氧化硫至饱和制得】，同时加以搅拌。当所有的溶液加完后，温度保持在0~2℃，一面搅拌，一面通入二氧化硫，直至溶液对刚果红试纸呈现酸性，或溶液颜色褪掉为止。在通二氧化硫时，可再加500g冰。将混合物移于12L烧瓶中，加入495g（625mL，8.5mol）丙酮，将溶液在蒸汽浴上加热至70℃，停止加热，把烧瓶用石棉布包起来以减少热量损失，放置过夜；然后用50%氢氧化钠溶液中和后，分出油层；水层用苯提取2~3次，合并油层和苯溶液，分去水，将油状物进行分馏，收集133~136℃的馏分，即为产品，产量420~480g，产率67%~76%。

丙酮肟海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

丙酮肟文献

Slow oxidation of acetoxime and methylethyl ketoxime to the corresponding nitronates and hydroxy nitronates by liver microsomes from rats, mice, and humans.

Toxicol. Sci. 47(2) , 144-50, (1999)

Acetoxime and methylethyl ketoxime (MEKO) are tumorigenic in rodents, inducing liver tumors in male animals. The mechanisms of tumorigenicity for these compounds are not well defined. Oxidation of the...

Synthesis and anticancer evaluation of benzyloxyurea derivatives.

Chem. Pharm. Bull. 62(9) , 898-905, (2014)

A series of novel benzyloxyurea derivatives was designed, synthesized by substituting different benzyls or phenyls on N,N'-positions of the hydroxyurea (HU). These target compounds were evaluated for ...

Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands.

Mol. Pharmacol. 71(1) , 357-65, (2007)

The presence of cis-configured exchangeable ligands has long been considered a prerequisite for antitumor activity of platinum complexes, but over the past few years, several examples violating this s...

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丙酮肟