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磺胺乙酰钠

磺胺乙酰钠用途

Sulfacetamide钠是抗炎化合物,可作用于皮肤和尿道感染。

磺胺乙酰钠名称

[ CAS 号 ]:
127-56-0

[ 中文名 ]:
磺胺乙酰钠

[ 英文名 ]:
Sulfacetamide sodium

[中文别名 ]:

[英文别名 ]:

Sulfacetamide sodium salt
Sodium acetyl[(4-aminophenyl)sulfonyl]azanide
UNII-30760ZE777
Sulfacetamide sodium anhydrous
Sulfacetamide sodium
SODIUM SULFACETAMIDE
Sulf 10
MFCD00149555
N-Acetylsulfanilamide Sodium Salt Hydrate
Sodium N-sulfanilylacetamide

磺胺乙酰钠生物活性

[ 描述 ]:

Sulfacetamide钠是抗炎化合物,可作用于皮肤和尿道感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Del Rosso, J.Q., Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis, 2004. 73(1 Suppl): p. 29-33.

[2]. Mastrolorenzo, A. and C.T. Supuran, Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs, 2000. 7(1): p. 49-54.

[3]. http://www.drugs.com/mtm/klaron.html

[4]. Roth, H.W., et al., [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd, 1992. 200(3): p. 182-6.

[相关活性小分子]

磺胺乙酰钠物理化学性质

[ 沸点 ]:
450.8ºC at 760 mmHg

[ 分子式 ]:
C₈H₉N₂NaO₃S

[ 分子量 ]:
236.223

[ 闪点 ]:
226.4ºC

[ 精确质量 ]:
236.023163

[ PSA ]:
88.85000

[ LogP ]:
1.93230

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 水溶解性 ]:
水溶性：可溶

磺胺乙酰钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8480000

CHEMICAL NAME :: Acetamide, N-sulfanilyl-, monosodium salt

CAS REGISTRY NUMBER :: 127-56-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H9-N2-O3-S.Na

MOLECULAR WEIGHT :: 236.24

WISWESSER LINE NOTATION :: ZR DSWMV1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 5 ppm

REFERENCE :: RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued. Volume(issue)/page/year: 6,161,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83071 No. of Facilities: 176 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 500 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83071 No. of Facilities: 185 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 6788 (estimated) No. of Female Employees: 3730 (estimated)

磺胺乙酰钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
AC8480000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2924299090

磺胺乙酰钠上下游产品

磺胺乙酰钠上游产品

磺胺乙酰钠下游产品

磺胺乙酰钠制备

磺胺经乙酰化，水解，成盐而得配料比(重量)为磺胺：乙酐：氢氧化钠(相对密度1.47-1.48)=1：0.61：1.59.将磺胺在47-50℃加入氢氧化钠溶液，在50±3℃加入适量的乙酐，控制pH12-13交替加入等量的乙酐及氢氧化钠溶液，共37次，加毕，再加氢氧化钠溶液调节pH至14以上，于70-74℃水解30min。pH 降至12，停止水解，冷至25℃，过滤，滤饼即磺胺乙酰钠粗品。精制：将粗品加入适量水中加热溶解，溶液浓度26-27℃ Be,65℃,调节pH至9.3-10，加活性炭脱色，趁热过滤，过滤冷却结晶。冷至30℃，过滤，干燥，得磺胺醋酰钠。

磺胺乙酰钠海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%