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4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺用途

Sulfamerazine(RP-2632)钠盐是磺胺类抗菌素。

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺名称

[ CAS 号 ]:
127-58-2

[ 中文名 ]:
4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺

[ 英文名 ]:
sulfamerazine sodium

[中文别名 ]:

磺胺甲嘧啶钠

[英文别名 ]:

EINECS 204-851-0
Sulfamerazin natrium
MFCD00068332
2-Sulfanilamido-4-methylpyrimidine sodium salt
Solumedine
UNII-JOV4UJY07O
Solfamerazina sodica [DCIT]
Sodium sulfamerazine
sulfamerazine sodium
Soluble sulfamerazine

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺生物活性

[ 描述 ]:

Sulfamerazine(RP-2632)钠盐是磺胺类抗菌素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131.

[相关活性小分子]

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺物理化学性质

[ 沸点 ]:
519.1ºC at 760mmHg

[ 熔点 ]:
216-219 °C

[ 分子式 ]:
C₁₁H₁₁N₄NaO₂S

[ 分子量 ]:
286.285

[ 闪点 ]:
267.8ºC

[ 精确质量 ]:
286.050049

[ PSA ]:
97.56000

[ LogP ]:
2.68880

[ 蒸汽压 ]:
7.03E-11mmHg at 25°C

[ 储存条件 ]:
2-8℃

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺MSDS

详细MSDS(安全技术说明书)

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0760000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-, monosodium salt

CAS REGISTRY NUMBER :: 127-58-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H11-N4-O2-S.Na

MOLECULAR WEIGHT :: 286.31

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& D1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1522 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1739 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H332

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/22

[ 安全声明 (欧洲) ]:
S7-S24-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3