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AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2用途

HIV蛋白酶底物IV是HIV蛋白酶的底物。HIV蛋白酶底物IV可用于测量HIV(人类免疫缺陷病毒)-1蛋白酶的活性[1]。

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2名称

[ CAS 号 ]:
128340-47-6

[ 中文名 ]:
AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2

[ 英文名 ]:
HIV Protease Substrate IV

[英文别名 ]:

HIV Substrate,KARVNleF(4-NO2)EANle-NH2

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2生物活性

[ 描述 ]:

HIV蛋白酶底物IV是HIV蛋白酶的底物。HIV蛋白酶底物IV可用于测量HIV(人类免疫缺陷病毒)-1蛋白酶的活性[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶

[参考文献]

[1]. Chaudhury S, et, al. Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance. Structure. 2009 Dec 9;17(12):1636-1648.

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2物理化学性质

[ 分子式 ]:
C₄₉H₈₃N₁₅O₁₃

[ 分子量 ]:
1090.28000

[ 精确质量 ]:
1089.63000

[ PSA ]:
472.95000

[ LogP ]:
5.10380

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2MSDS

详细MSDS(安全技术说明书)

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

AC-ALA-ARG-VAL-LEU-ALA-GLU-ALA-NH2文献

Characterization of the murine leukemia virus protease and its comparison with the human immunodeficiency virus type 1 protease.

J. Gen. Virol. 87(Pt 5) , 1321-30, (2006)

The protease (PR) of Murine leukemia virus (MLV) was expressed in Escherichia coli, purified to homogeneity and characterized by using various assay methods, including HPLC-based, photometric and fluo...

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

FEBS J. 272(20) , 5265-77, (2005)

HIV-1 protease (PR) and two drug-resistant variants--PR with the V82A mutation (PR(V82A)) and PR with the I84V mutation (PR(I84V))--were studied using reduced peptide analogs of five natural cleavage ...

Interactions of a novel inhibitor from an extremophilic Bacillus sp. with HIV-1 protease: implications for the mechanism of inactivation.

J. Biol. Chem. 276(4) , 2487-93, (2001)

The active site cleft of the HIV-1 protease (PR) is bound by two identical conformationally mobile loops known as flaps, which are important for substrate binding and catalysis. The present article re...

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