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甲氧西林钠

甲氧西林钠用途

Methicillin是β-内酰胺抗生素,其通过抑制参与肽聚糖合成的青霉素结合蛋白起作用。

甲氧西林钠名称

[ CAS 号 ]:
132-92-3

[ 中文名 ]:
甲氧西林钠

[ 英文名 ]:
Methicillin SodiuM

[英文别名 ]:

甲氧西林钠生物活性

[ 描述 ]:

Methicillin是β-内酰胺抗生素,其通过抑制参与肽聚糖合成的青霉素结合蛋白起作用。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠 | 氯霉素

甲氧西林钠物理化学性质

[ 沸点 ]:
640ºC at 760 mmHg

[ 熔点 ]:
196-197℃

[ 分子式 ]:
C17H19N2NaO6S

[ 分子量 ]:
402.39700

[ 闪点 ]:
340.9ºC

[ 精确质量 ]:
402.08600

[ PSA ]:
133.30000

[ 外观性状 ]:
white to off-white

[ 蒸汽压 ]:
2.94E-17mmHg at 25°C

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Slightly soluble in acetone. Soluble in ethanol or water

甲氧西林钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH8950000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3-dimethyl- 7-oxo-, monosodium salt
CAS REGISTRY NUMBER :
132-92-3
LAST UPDATED :
199709
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H19-N2-O6-S.Na
MOLECULAR WEIGHT :
402.43
WISWESSER LINE NOTATION :
T45 ANV ESTJ CMVR BO1 FO1& F1 F1 GVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
600 mg/kg/3D
TOXIC EFFECTS :
Liver - other changes Blood - leukopenia Blood - eosinophilia
REFERENCE :
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 135,52,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,826,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,619,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,826,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4186 No. of Facilities: 272 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 11353 (estimated) No. of Female Employees: 7943 (estimated)

甲氧西林钠安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
36/37/38-42/43

[ 安全声明 (欧洲) ]:
26-36

[ RTECS号 ]:
XH8950000

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产品详情:甲氧西林钠


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¥需询单/1g

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产品详情:甲氧西林钠


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