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2-氨基苯并噻唑

2-氨基苯并噻唑用途

苯并[d]噻唑-2-胺是合成含氮杂环的双核配合物的有利配体[1]。

2-氨基苯并噻唑名称

[ CAS 号 ]:
136-95-8

[ 中文名 ]:
2-氨基苯并噻唑

[ 英文名 ]:
Benzo[d]thiazol-2-amine

[中文别名 ]:

[英文别名 ]:

Benzo[d]thiazol-2-amine
2-Benzothiazolamine
2-Aminobenzothiazole
Benzothiazole-2-ylamine
1,3-Benzothiazol-2-amine
EINECS 205-268-4
MFCD00005785

2-氨基苯并噻唑生物活性

[ 描述 ]:

苯并[d]噻唑-2-胺是合成含氮杂环的双核配合物的有利配体[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

2-氨基苯并噻唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
307.5±25.0 °C at 760 mmHg

[ 熔点 ]:
126-129 °C(lit.)

[ 分子式 ]:
C₇H₆N₂S

[ 分子量 ]:
150.201

[ 闪点 ]:
139.8±23.2 °C

[ 精确质量 ]:
150.025162

[ PSA ]:
67.15000

[ LogP ]:
1.89

[ 外观性状 ]:
无气味的灰色至白色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC

2-氨基苯并噻唑MSDS

2-氨基苯并噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL1050000

CHEMICAL NAME :: Benzothiazole, 2-amino-

CAS REGISTRY NUMBER :: 136-95-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H6-N2-S

MOLECULAR WEIGHT :: 150.21

WISWESSER LINE NOTATION :: T56 BN DSJ CZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 126 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2500 ug/plate

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 23,695,1985

2-氨基苯并噻唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DL1050000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2934200090

2-氨基苯并噻唑合成路线

2-氨基苯并噻唑上下游产品

2-氨基苯并噻唑上游产品

2-氨基苯并噻唑下游产品

2-氨基苯并噻唑制备

由苯基硫脲与氯化硫反应得到。先将无水氯仿吸入搪玻璃锅中，于搅拌下加入苯基硫脲，慢慢升温到60-63℃，蒸出含水氯仿，冷却至40℃加入氯化硫，气相温度不高于40℃，以免物料结块。加完后4h逐步升温至61℃，在61-64℃回流反应10h。然后将其排到盛有一定水量和活性炭的蒸馏锅中，用直接蒸汽蒸馏回收氯仿到液相温度为98℃，并维持15min。回收完毕，加水稀释，加冰冷却，加液碱中和至pH值为4.1，再加活性炭后搅拌。冷却、抽滤，滤液用30%液碱中和至pH值为7.0-7.6，然后冷却到35-40℃，压滤、烘干（温度不超过80℃）即得成品。熔点128-130℃，收率74.4%。

2-氨基苯并噻唑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基苯并噻唑文献

Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.

Bioorg. Med. Chem. 17 , 5275-84, (2009)

In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the anti...

Simultaneous determination of benzothiazoles, benzotriazoles and benzosulfonamides by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry in environmental aqueous matrices and human urine

J. Chromatogr. A. 1338 , 164-73, (2014)

• Benzothiazoles, benzotriazoles and benzosulfonamides determination in aqueous matrices. • New environmental-friendly and high-throughput protocol developed by SPME-GC-QqQMS. • Sample preparation str...

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

J. Med. Chem. 54 , 211-221, (2011)

Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify n...

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