二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲用途

DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC50: 0.007-0.096 渭M). DpC synergizes with multiple anti-cancer therapeutics[1].

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲名称

[ CAS 号 ]:
1382469-39-7

[ 中文名 ]:
二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲

[ 英文名 ]:
DpC

[英文别名 ]:

DPC
MFCD22666593

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲生物活性

[ 描述 ]:

DpC是一种抗肿瘤药物。DpC抑制癌症细胞增殖(IC50:0.007-0.096渭M) 。DpC与多种抗癌疗法协同作用[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Dharmasivam M, et al. The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells. Biochim Biophys Acta Gen Subj. 2022 Aug;1866(8):130152.

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
510.7±48.0 °C at 760 mmHg

[ 分子式 ]:
C₁₉H₂₃N₅S

[ 分子量 ]:
353.48

[ 闪点 ]:
262.7±29.6 °C

[ 精确质量 ]:
353.167419

[ LogP ]:
3.27

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.649

[ 储存条件 ]:
20°C

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

二-2-吡啶酮-4-环己基-4-甲基-3-氨基硫脲文献

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.

Oncotarget 6 , 8851-74, (2015)

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including t...

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.

J. Biol. Chem. 291 , 1029-52, (2016)

N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pa...

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