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氨三乙酸

氨三乙酸用途

硝基三乙酸是一种氨基三羧酸。硝基三乙酸可以用作螯合剂,与金属离子形成配位化合物[1]。

氨三乙酸名称

[ CAS 号 ]:
139-13-9

[ 中文名 ]:
次氮基三乙酸

[ 英文名 ]:
nitrilotriacetic acid

[中文别名 ]:

[英文别名 ]:

nitrilotriacetate
combretastatin A2
aminotriacetic acid
Prochlorperazin
MFCD00004287
2,2',2''-Nitrilotriacetic acid
tri(carboxymethyl)amine
Triglycine
Nitrilotriessigsaeure
EINECS 205-355-7

氨三乙酸生物活性

[ 描述 ]:

硝基三乙酸是一种氨基三羧酸。硝基三乙酸可以用作螯合剂,与金属离子形成配位化合物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

氨三乙酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
498.2±40.0 °C at 760 mmHg

[ 熔点 ]:
245 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₉NO₆

[ 分子量 ]:
191.139

[ 闪点 ]:
255.1±27.3 °C

[ 精确质量 ]:
191.042984

[ PSA ]:
115.14000

[ LogP ]:
-1.76

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
Insoluble.

氨三乙酸MSDS

氨三乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ0175000

CHEMICAL NAME :: Acetic acid, nitrilotri-

CAS REGISTRY NUMBER :: 139-13-9

BEILSTEIN REFERENCE NO. :: 1710776

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C6-H9-N-O6

MOLECULAR WEIGHT :: 191.16

WISWESSER LINE NOTATION :: QV1N1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 41292 mg/kg/7W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29439 ug/kg/4W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 gm/kg/75W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 832 gm/kg/66W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 2 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80058 No. of Facilities: 1115 (estimated) No. of Industries: 31 No. of Occupations: 32 No. of Employees: 13454 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80058 No. of Facilities: 1082 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 25216 (estimated) No. of Female Employees: 7169 (estimated)

氨三乙酸安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H351

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S36/37-S45-S36/37/39

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ RTECS号 ]:
AJ0175000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
29224995

氨三乙酸合成路线

氨三乙酸上下游产品

氨三乙酸上游产品

氨三乙酸下游产品

氨三乙酸制备

1.由氯乙酸与氢氧化钠反应生成氯乙酸钠，然后氯化铵反应生成氨基三乙酸钠，再经酸化即得成品。氯乙酸法工艺落后，成本高，国外已淘汰。美国、日本大量副产HCN的厂家采用斯脱里格法，纯的液体HCN和甲醛在酸性条件下与氨或胺盐反应生成氮川三乙腈，再水解得到NTA。该法投资和操作费用高，安全性差。另一种方法是国外70年代开发成功的羧甲基化法。该法采用NaCN，便于贮运，反应的碱性条件下进行，不产生易挥发的HCN，生产安全性好。

2.由氯乙酸与氢氧化钠反应生成氯乙酸钠，然后与氯化铵反应生成氨基三乙酸钠，再经酸化即得成品。

3.将甘氨酸和碘乙酸溶于水中，加氢氧化钾溶液加热至80℃，冷却，然后用盐酸酸化，即有亚氨基三乙酸析出，在热水中重结晶即得纯品：

4.将885kg一氯乙酸投入耐酸釜中，搅拌下加热至64℃，全熔融后滴加1220kg30%的液碱进行中和反应。在80～90℃反应5～6h。得到一氯乙酸钠水溶液。将中和液送入薄膜蒸发器中，在真空下浓缩。接近饱和时打入缩合釜，加热到60℃，用碳酸钠饱和溶液调ph值至7～8。继续升温至80℃，在搅拌下加入400kg氯化铵饱和溶液。加毕后，再搅5min，混合均匀。再用液碱调ph 值至9～10。停止反应。静置4h 。过滤。收集滤液。将滤液打入酸化釜中，加盐酸酸化，当ph值达到0.5～1.2时，停止加酸。冷却静置，结晶。将上层液吸出，用水洗涤结晶数次，干燥得成品。反应式如下：

氨三乙酸海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

氨三乙酸文献

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Defining the conformational states of cytochrome P450 active sites is critical for the design of agents that minimize drug-drug interactions, the development of isoform-specific P450 inhibitors, and t...

Cytosolic Hsp60 can modulate proteasome activity in yeast.

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Hsp60, an essential oligomeric molecular mitochondrial chaperone, has been subject to rigorous basic and clinical research. With yeast as a model system, we provide evidence for the ability of cytosol...

Effects of actin-like proteins encoded by two Bacillus pumilus phages on unstable lysogeny, revealed by genomic analysis.

Appl. Environ. Microbiol. 81(1) , 339-50, (2014)

We characterized two newly isolated myoviruses, Bp8p-C and Bp8p-T, infecting the ginger rhizome rot disease pathogen Bacillus pumilus GR8. The plaque of Bp8p-T exhibited a clear center with a turbid r...

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