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羟乙磺酸喷他脒

羟乙磺酸喷他脒用途

Pentamidine羟乙基磺酸是一抗生素试剂,临床上用于肺囊虫肺炎的预防和治疗。

羟乙磺酸喷他脒名称

[ CAS 号 ]:
140-64-7

[ 中文名 ]:
喷他脒羟乙磺酸盐

[ 英文名 ]:
Pentamidine isethionate

[中文别名 ]:

[英文别名 ]:

Pentamidine isethionate salt
MFCD00079213
EINECS 205-424-1
Pentamidine isethionate
4,4'-Diamidino-a,w-diphenoxypentane Isethionate
Pentamidine diisetionate

羟乙磺酸喷他脒生物活性

[ 描述 ]:

Pentamidine羟乙基磺酸是一抗生素试剂,临床上用于肺囊虫肺炎的预防和治疗。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

羟乙磺酸喷他脒物理化学性质

[ 沸点 ]:
539.4ºC at 760mmHg

[ 熔点 ]:
188-194 °C(lit.)

[ 分子式 ]:
C₂₃H₃₆N₄O₁₀S₂

[ 分子量 ]:
592.683

[ 闪点 ]:
280ºC

[ 精确质量 ]:
592.187256

[ PSA ]:
284.16000

[ LogP ]:
4.37750

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
1.06E-11mmHg at 25°C

[ 储存条件 ]:
−20°C

羟乙磺酸喷他脒MSDS

羟乙磺酸喷他脒毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6500000

CHEMICAL NAME :: Benzamidine, 4,4'-(pentamethylenedioxy)di-, bis(beta-hydroxyethanesulfonate)

CAS REGISTRY NUMBER :: 140-64-7

LAST UPDATED :: 199603

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C19-H24-N4-O2.C4-H12-O8-S2

MOLECULAR WEIGHT :: 592.75

WISWESSER LINE NOTATION :: MUYZR DO5OR DYZUM &WSQ2Q 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 21429 ug/kg/5D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Skin and Appendages - sweating

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 24 mg/kg/6D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 68 mg/kg/17D-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 6 mg/kg/D

TOXIC EFFECTS :: Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 26 mg/kg/9D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15100 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 756 mg/kg/6W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 112 mg/kg/2W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 24 mg/kg

SEX/DURATION :: female 6-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 29500 ug/L

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 1,103,1983

羟乙磺酸喷他脒安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38;R43

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
CV6500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

羟乙磺酸喷他脒合成路线

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羟乙磺酸喷他脒文献

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Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro.

J. Neurosci. 12 , 970, (1992)

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