安福霉素

安福霉素用途

Amphomycin是一种抑制肽聚糖合成并阻止细胞壁发育的脂肽抗生素。氨苄霉素对耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)、耐青霉素-庆大霉素-红霉素肺炎链球菌和耐利奈唑胺奎宁司汀-达福司汀肠球菌具有强大的抗菌活性[1][2][3]。

安福霉素名称

[ CAS 号 ]:
1402-82-0

[ 中文名 ]:
安福霉素

[ 英文名 ]:
Amphomycin

安福霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

氨苄霉素(40μg/mL；60分钟)导致金黄色葡萄球菌表现出细胞壁变薄和朴氏核苷酸积累[1]。细胞活力测定[1]细胞系：金黄色葡萄球菌全细胞浓度：40μg/mL培养时间：60分钟结果：导致细胞壁变薄和朴氏核苷酸的积累。

[体内研究]

氨苄霉素(50 mg/kg；口服；单药)的口服有效性较低,(5-10mg/kg；静脉注射；单剂)的半衰期较长(小鼠为5.2-8.0小时,大鼠为4.6-7.1小时)[2]。

安福霉素物理化学性质

[ 密度 ]:
1.37g/cm3

[ 沸点 ]:
1693.3ºC at 760 mmHg

[ 分子式 ]:
C₅₈H₉₁N₁₃O₂₀

[ 分子量 ]:
1290.42000

[ 闪点 ]:
977.9ºC

[ 精确质量 ]:
1289.65000

[ PSA ]:
506.84000

[ LogP ]:
0.52660

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.599

安福霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BU2100000

CHEMICAL NAME :: Amphomycin

CAS REGISTRY NUMBER :: 1402-82-0

LAST UPDATED :: 199109

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),317,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 233 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 30,9,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,131,1967