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1-壬醇

1-壬醇用途

壬烷-1-醇是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

1-壬醇名称

[ CAS 号 ]:
143-08-8

[ 中文名 ]:
正壬醇

[ 英文名 ]:
1-Nonanol

[中文别名 ]:

[英文别名 ]:

1-Nonanol
1,1-dimethoxy-nonane
nonanal dimethylacetal
Nonyl Alcohol
EINECS 205-583-7
Nonane,1,1-dimethoxy
n-Nonyl alcohol
1-nonanal dimethyl acetal
nonylaldehyde dimethylacetal
pelargonaldehyde dimethyl acetal

1-壬醇生物活性

[ 描述 ]:

壬烷-1-醇是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

1-壬醇物理化学性质

[ 密度 ]:
0.827 g/mL at 25 °C(lit.)

[ 沸点 ]:
215 °C(lit.)

[ 熔点 ]:
−8-−6 °C(lit.)

[ 分子式 ]:
C₉H₂₀O

[ 分子量 ]:
144.25400

[ 闪点 ]:
208 °F

[ 精确质量 ]:
144.15100

[ PSA ]:
20.23000

[ LogP ]:
2.72930

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽密度 ]:
5 (vs air)

[ 蒸汽压 ]:
13 mm Hg ( 104 °C)

[ 折射率 ]:
n20/D 1.433(lit.)

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1 g/L (20 ºC)

1-壬醇MSDS

1-壬醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB1575000

CHEMICAL NAME :: Nonyl alcohol

CAS REGISTRY NUMBER :: 143-08-8

BEILSTEIN REFERENCE NO. :: 0969213

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C9-H20-O

MOLECULAR WEIGHT :: 144.29

WISWESSER LINE NOTATION :: Q9

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4628,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4628,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,94,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4628,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5660 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,95,1973

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4360 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(5),61,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 19 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(5),61,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35295 mg/kg

SEX/DURATION :: female 1-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970- Volume(issue)/page/year: 22(1),71,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35295 mg/kg

SEX/DURATION :: female 1-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970- Volume(issue)/page/year: 22(1),71,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84362 No. of Facilities: 94 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 21547 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84362 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

1-壬醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H412

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R20;R51/53

[ 安全声明 (欧洲) ]:
S23-S24/25-S61-S29

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
RB1575000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
2905199090

1-壬醇合成路线

1-壬醇上下游产品

1-壬醇上游产品

1-壬醇下游产品

1-壬醇制备

1. 工业上可有多种生产方法。丙烯在磷酸或氟化硼存在下聚合得壬烯，由壬烯水合可得壬醇。丁烷-丁烯馏分中的异丁烯经二聚得二异丁烯和混合辛烯，再经羰基化而得壬醇和混合壬醇。壬酸乙酯与金属钠在乙醇溶液中还原得到壬醇。

2. 溴化庚烷与环氧乙烷经下列反应可得到壬醇。

3. 由壬酸乙酯与金属钠在乙醇溶液中还原而得。

4. 烟草：FC，40。

5.制法：

首先用24.5g(1mol)镁屑、179g(1.0mol)1-溴庚烷和300mL二丁醚^①按常规方法制备Grignard试剂。冷至0℃，剧烈搅拌下，通入过滤的环氧乙烷(2)，保持反应体系的温度在0℃左右，通完后反应1h。而后升温至40℃反应1h。再水浴加热反应2h。冷却，将反应物倒入冰水中，稀硫酸酸化，以溶解生成的氢氧化镁。铵上述1-己醇的处理方法进行处理，收集95～100℃/1.6kPa的馏分，得1-壬醇(1)95g，收率69%。注：①二丁醚的纯化方法如下：依次用氢氧化钠溶液、水洗涤，无水氯化钙干燥，而后分馏，收集140～142℃的馏分。[1]

1-壬醇海关

[ 海关编码 ]: 2905199090

[ 中文概述 ]:
2905199090. 其他饱和一元醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905199090. saturated monohydric alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

1-壬醇文献

Determination of low levels of benzodiazepines and their metabolites in urine by hollow-fiber liquid-phase microextraction (LPME) and gas chromatography-mass spectrometry (GC-MS).

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 24-33, (2014)

In this study, it is shown a method for the determination of benzodiazepines and their main metabolites in urine samples by hollow-fiber liquid-phase microextraction (LPME) in the three-phase mode. In...

Evaluation of injection methods for fast, high peak capacity separations with low thermal mass gas chromatography.

J. Chromatogr. A. 1392 , 82-90, (2015)

Low thermal mass gas chromatography (LTM-GC) was evaluated for rapid, high peak capacity separations with three injection methods: liquid, headspace solid phase micro-extraction (HS-SPME), and direct ...

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

J. Insect Physiol. 78 , 33-46, (2015)

Phytophagous insects detect volatile compounds produced by host and non-host plants, using species-specific sets of olfactory receptor neurons (ORNs). To investigate the relationship between the range...

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