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1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯用途

Musk tibetene (Musk tibetine) 是一种硝基麝香化合物,具有抗癌活性。Musk tibetine 在人淋巴细胞和人肝癌细胞系的微核试验中显示无基因毒性。

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯名称

[ CAS 号 ]:
145-39-1

[ 中文名 ]:
西藏麝香

[ 英文名 ]:
Musk tibetene

[中文别名 ]:

[英文别名 ]:

5-tert-Butyl-4,6-dinitro-1,2,3-trimethylbenzene
EINECS 205-651-6
Musk tibetine
1-tert-butyl-3,4,5-trimethyl-2,6-dinitro-benzene
Musk tibetene
Musk Tebetine
Nitromusk tibetene
1-tert-Butyl-3,4,5-trimethyl-2,6-dinitrobenzene
2-tert-Butyl-1,3-dinitro-4,5,6-trimethylbenzene
Tibetene musk

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯生物活性

[ 描述 ]:

Musk tibetene (Musk tibetine) 是一种硝基麝香化合物,具有抗癌活性。Musk tibetine 在人淋巴细胞和人肝癌细胞系的微核试验中显示无基因毒性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

在用人淋巴细胞和人肝癌细胞株Hep G2进行的微核试验中,藏麝香显示没有遗传毒性[1]。在我们的宿主介导的检测系统中,藏麝香显示出一种细胞转化潜能,显示出剂量依赖性反应[2]。

[参考文献]

[1]. Kevekordes S, et al. Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Toxicol Lett. 1997 Mar 14;91(1):13-7.

[2]. Apostolidis S, et al. Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. Anticancer Res. 2002 Sep-Oct;22(5):2657-62.

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
391.0±42.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₈N₂O₄

[ 分子量 ]:
266.293

[ 闪点 ]:
174.6±20.7 °C

[ 精确质量 ]:
266.126648

[ PSA ]:
91.64000

[ LogP ]:
4.68

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
室温

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7220000

CHEMICAL NAME :: Benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl-

CAS REGISTRY NUMBER :: 145-39-1

BEILSTEIN REFERENCE NO. :: 2000732

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H18-N2-O4

MOLECULAR WEIGHT :: 266.33

WISWESSER LINE NOTATION :: WNR B1 C1 D1 ENW FX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2783 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯安全信息

[ 海关编码 ]:
2904209090

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯合成路线

详细合成路线

1-叔丁基-3,4,5-三甲基-2,6-二硝基-苯海关

[ 海关编码 ]: 2904209090

[ 中文概述 ]:
2904209090 其他仅含硝基或亚硝基的衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%