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盐酸司来吉兰

盐酸司来吉兰用途

R-(-)-Deprenyl盐酸盐是不可逆的MAO-B选择性抑制剂。

盐酸司来吉兰名称

[ CAS 号 ]:
14611-52-0

[ 中文名 ]:
盐酸司来吉兰

[ 英文名 ]:
Selegiline HCl

[中文别名 ]:

盐酸丙炔苯并胺

[英文别名 ]:

MFCD00069299
(-)-Deprenyl hydrochloride
(-)-Deprenil hydrochloride
selegiline hydrochloride
(R)-(-)-Deprenyl hydrochloride
R-(−)-Deprenyl hydrochloride
Selegiline HCl
(R)-selegiline hydrochloride
R-(-)-Deprenyl (hydrochloride)

盐酸司来吉兰物理化学性质

[ 密度 ]:
0.954g/cm3

[ 沸点 ]:
272.5ºC at 760mmHg

[ 熔点 ]:
141-142ºC

[ 分子式 ]:
C₁₃H₁₈ClN

[ 分子量 ]:
223.742

[ 闪点 ]:
108.4ºC

[ 精确质量 ]:
223.112778

[ PSA ]:
3.24000

[ LogP ]:
2.98460

[ 外观性状 ]:
白色结晶固体

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
H2O: >10 mg/mL

盐酸司来吉兰MSDS

详细MSDS(安全技术说明书)

盐酸司来吉兰毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA0292500

CHEMICAL NAME :: Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 14611-52-0

LAST UPDATED :: 199606

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H17-N.Cl-H

MOLECULAR WEIGHT :: 223.77

WISWESSER LINE NOTATION :: 1UU2N1&Y1&1R &GH --

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1904 mg/kg

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19(Suppl 1),93,1994

盐酸司来吉兰安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S26

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
DA0292500

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2921519090

盐酸司来吉兰上下游产品

盐酸司来吉兰上游产品

盐酸司来吉兰下游产品

盐酸司来吉兰海关

[ 海关编码 ]: 2921519090

[ 中文概述 ]:
2921519090. 间-、对-苯二胺、二氨基甲苯等〔包括衍生物及它们的盐〕. 增值税率:17.0%. 退税率:17.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸司来吉兰文献

Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol.

Molecules 20 , 7454-73, (2015)

The inhibitory effects of flavonoids on monoamine oxidases (MAOs) have attracted great interest since alterations in monoaminergic transmission are reported to be related to neurodegenerative diseases...

[Liver monoamine oxidase activity of the lamprey Lampetra fluviatilis. the substrate-inhibitory specificity].

Zh. Evol. Biokhim. Fiziol. 49(1) , 39-43, (2013)

Based on data of substrate-inhibitory analysis with use of specific inhibitors--deprenyl, chlorgi-lin--and specific substrates--serotonin, noradrenalin, benzylamine, beta-phenylethylamine, and N-methy...

Modulations of brain amines and dopaminergic behavior by a novel, reversible and selective MAO-B inhibitor.

Brain Res. 1470 , 45-51, (2012)

Monoamine oxidase (MAO) B is a validated target for many neurodegenerative diseases. Recently we have reported a few pyrazolines as reversible and selective MAO-B inhibitors. Amongst them, we have sel...

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