14611-52-0

• 常用中文名：盐酸司来吉兰
• 常用英文名：Selegiline HCl
• CAS号：14611-52-0
• 分子式：C₁₃H₁₈ClN
• 分子量：223.742
• 相关类别： 原料药 消化系统用药 食欲抑制药及其它减肥药
• 发布时间：2018-08-15 18:11:06
• 更新时间：2024-01-02 19:10:48
• R-(-)-Deprenyl盐酸盐是不可逆的MAO-B选择性抑制剂。

名称

• 中文名: 盐酸司来吉兰
• 英文名: selegiline hydrochloride
• 中文别名: 盐酸丙炔苯并胺; (R)-N,alpha-二甲基-N-(2-丙炔基)苯乙胺盐酸盐
• 英文别名: N-Methyl-N-[(2R)-1-phenyl-2-propanyl]-2-propyn-1-amine hydrochloride (1:1); (R)-N-Methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine hydrochloride; N-Methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine hydrochloride (1:1); MFCD00069299; (-)-(R)-N,α-Dimethyl-N-2-propynylphenethylamine monohydrochloride; (-)-Deprenyl hydrochloride; N-méthyl-N-[(1R)-1-méthyl-2-phényléthyl]prop-2-yn-1-amine chlorhydrate; benzeneethanamine, N,α-dimethyl-N-2-propynyl-, (αR)-, hydrochloride; (-)-Deprenil hydrochloride; selegiline hydrochloride; (R)-(-)-Deprenyl hydrochloride; R-(−)-Deprenyl hydrochloride; benzeneethanamine, N,a-dimethyl-N-2-propyn-1-yl-, (aR)-, hydrochloride (1:1); (R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride; N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine hydrochloride; (-)-(R)-N,α-Dimethyl-N-2-propynylphenethylamine hydrochloride; N-methyl-N-[(1R)-1-methyl-2-phenylethyl]prop-2-yn-1-amine hydrochloride; Selegiline HCl; N-Methyl-N-[(1R)-1-methyl-2-phenylethyl]prop-2-in-1-aminhydrochlorid; (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine,hydrochloride; (R)-selegiline hydrochloride; Benzeneethanamine, N,α-dimethyl-N-2-propyn-1-yl-, (αR)-, hydrochloride (1:1); R-(-)-Deprenyl (hydrochloride)

物化性质

• 密度: 0.954g/cm3
• 沸点: 272.5ºC at 760mmHg
• 熔点: 141-142ºC
• 分子式: C₁₃H₁₈ClN
• 分子量: 223.742
• 闪点: 108.4ºC
• 精确质量: 223.112778
• PSA: 3.24000
• LogP: 2.98460
• 外观性状: 白色结晶固体
• 储存条件: Store at RT
• 水溶解性: H2O: >10 mg/mL

MSDS

Section 1. Chemical Product and Company Identification Selegiline Hydrochloride Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chemical Family Selegiline Hydrochloride Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various SubstancesNon-flammable in presence of shocks. Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Selegiline Hydrochloride Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystalline powde)OdorNot available. Not available. Taste 223.75 g/mole Molecular Weight ColorWhite. pH (1% soln/water)Not available. Boiling PointNot available. Melting Point141°C (285.8°F) - 145 C. Not available. Critical Temperature Specific GravityNot available. Not applicable. Vapor Pressure Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Not available. Ionicity (in Water) Dispersion PropertiesSee solubility in water. Soluble in cold water, hot water. Solubility Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Excess heat Conditions of Instability Incompatibility with various Not available. substances CorrosivityNot available. Selegiline Hydrochloride Sensitive to light. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 385 mg/kg [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onHazardous in case of ingestion. HumansSlightly hazardous in case of skin contact (irritant), of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic) based on animal test data Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Harmful if swallowed. May cause gastrointestinal tract irritation with nausea, high fever, inability to keep mouth open (trismus), hyperextension and spasticity, increased or profuse sweating (diaphoresis). May affect behavior/Cental Nervous System (agitation, anxiety, hallucinations, drowsiness, dizziness, faintness, irritability, hyperactivity, confusion), cardiovascular system (hypotension, hypertension, irregular pulse, rapid pulse, vascular collapse, seizures, coma), respiration (respiratory depression or failure). It is metobolized to Methylamphetamine and Amphetamine (-) isomers. Conditions aggravated by exposure: Allergic reaction to amphetamine, ephedrine, etc., pregnancy, glaucoma, over active thyroid, severe anxiety. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are less toxic than the product itself. of Biodegradation Not available. Special Remarks on the Products of Biodegradation Section 13. Disposal Considerations Waste must be disposed of in accordance with federal, state and local environmental Waste Disposal control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Special Provisions forNot applicable. Transport Selegiline Hydrochloride DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California prop. 65: This product contains the following ingredients for which the State of California has California found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). Other Classifications DSCL (EEC)R22- Harmful if swallowed.S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Selegiline Hydrochloride SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DA0292500 CHEMICAL NAME : Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, hydrochloride, (R)- CAS REGISTRY NUMBER : 14611-52-0 LAST UPDATED : 199606 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H17-N.Cl-H MOLECULAR WEIGHT : 223.77 WISWESSER LINE NOTATION : 1UU2N1&Y1&1R &GH -- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 81 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 121 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 32,377,1967 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1904 mg/kg SEX/DURATION : male 9 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19(Suppl 1),93,1994

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): S22-S26
• 危险品运输编码: UN 3249
• WGK德国: 3
• RTECS号: DA0292500
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2921519090

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海关

海关编码	2921519090
中文概述	2921519090. 间-、对-苯二胺、二氨基甲苯等〔包括衍生物及它们的盐〕. 增值税率:17.0%. 退税率:17.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%